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Titolo:
CHARACTERIZATION OF CHOLECYSTOKININ RECEPTORS IN CANINE INTESTINAL CIRCULAR MUSCLE
Autore:
MAO YK; WANG YF; DANIEL EE;
Indirizzi:
MCMASTER UNIV,DEPT BIOMED SCI,DIV PHYSIOL & PHARMACOL,1200 MAIN ST W HAMILTON ON L8N 3Z5 CANADA MCMASTER UNIV,DEPT BIOMED SCI,DIV PHYSIOL & PHARMACOL HAMILTON ON L8N3Z5 CANADA
Titolo Testata:
Peptides
fascicolo: 6, volume: 16, anno: 1995,
pagine: 1025 - 1029
SICI:
0196-9781(1995)16:6<1025:COCRIC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; SYMPATHETIC-GANGLION; GASTRIN RECEPTOR; COLON DISTENSION; ANTAGONISTS; BINDING; CELLS; ILEUM; CONTRACTION;
Keywords:
L364,718; L365,260; GASTRIN-17; YM022; CCKA RECEPTOR; DEEP MUSCULAR PLEXUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y.K. Mao et al., "CHARACTERIZATION OF CHOLECYSTOKININ RECEPTORS IN CANINE INTESTINAL CIRCULAR MUSCLE", Peptides, 16(6), 1995, pp. 1025-1029

Abstract

We localized and characterized the binding of [H-3](+/-)-L364,718 in canine small intestine circular muscle. The highest densities of [H-3]L364,718 binding were located in the fraction enriched in deep muscular plexus synaptosomal membranes. In this fraction [H-3]L364,718 binding was of high density (B-max 136.78 +/- 53.66 fmol/mg) and high affinity (K-d 1.67 +/- 0.74 nM). Kinetics studies revealed that binding was reversible and yielded a similar K-d value. L364,718, CCK-8-S, and L365,260 fully displaced [H-3]L364,718 binding, but ligands at CCKB receptors, gastrin-17, and YM022 did not. Therefore, CCKA receptors in canine intestine circular muscle are located on nerve endings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:01:45