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Titolo:
FAILURE OF PLASMA ATRIAL-NATRIURETIC-PEPTIDE LEVELS TO INCREASE DURING EXERCISE IN PATIENTS WITH CHRONIC ATRIAL-FIBRILLATION
Autore:
KELLY PA; MACAULAYHUNTER E; ASTRIDGE PS; LOWRY PJ; PERRINS EJ; KAYE GC;
Indirizzi:
CASTLE HILL HOSP,MRCP KINGSTON HULL HU16 5JN N HUMBERSIDE ENGLAND LEEDS GEN INFIRMARY,DEPT CARDIOL LEEDS W YORKSHIRE ENGLAND UNIV READING,DEPT BIOCHEM READING BERKS ENGLAND
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 1, volume: 20, anno: 1997,
parte:, 1
pagine: 10 - 16
SICI:
0147-8389(1997)20:1<10:FOPALT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; PRESSURE; RELEASE; CARDIOVERSION; BLOCK; DOGS; ANP;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; CHRONIC ATRIAL FIBRILLATION; EXERCISE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Kelly et al., "FAILURE OF PLASMA ATRIAL-NATRIURETIC-PEPTIDE LEVELS TO INCREASE DURING EXERCISE IN PATIENTS WITH CHRONIC ATRIAL-FIBRILLATION", PACE, 20(1), 1997, pp. 10-16

Abstract

It is generally accepted that plasma accepted natriuretic peptide release occurs secondary to atrial stretch. The influence of coordinated atrial contraction (AC) upon this process is not fully appreciated. The aim of the study was to determine the importance of coordinated AC upon peripheral atrial natriuretic peptide levels (alpha-hANP) during exercise. Peripheral alpha-hANP levels were measured at rest and duringexercise in 12 patients with complete heart block (CHB) and permanentrate responsive pacemakers. Seven patients had coordinated AC and five had chronic atrial fibrillation (AF). Each patient performed three treadmill exercise tests. Maximal inspired oxygen volume (VO2 max) was determined during test 1. Tests 2 and 3 were performed to 70% VO2 max,the pacemaker being programmed to either VVI or VVIR mode. Plasma alpha-hANP was measured using a two-site immunoradiometric assay. At restthere was a small but significant difference between the two patient groups: AF 60.2 pg/mL versus AC 97.6 pg/mL; P = 0.03. During exercise in the AC patients, were was a significant increase in alpha-hANP levels, in VVIR mode, to 238.4 pg/mL, and in VVI mode, to 207.9 pg/mL, P =0.002 and 0.003, respectively. In those patients with chronic AF, there was no significant rise or fall in alpha-hANP levels in either pacing mode, VVIR 65.2 pg/mL, VVI 46.6 pg/mL. Previous workers have suggested that alpha-hANP release by nonfunctioning atria is normal. We haveshown that the presence of coordinated AC is required for the releaseof alpha-hANP during exercise in patients with CHB, and that this appears to be independent of ventricular rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:22:41