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Titolo:
LOCAL VERSUS SYSTEMIC IMMUNOTOXICITY OF ISOBUTYL NITRITE FOLLOWING SUBCHRONIC INHALATION EXPOSURE OF FEMALE B6C3F1 MICE
Autore:
RATAJCZAK HV; THOMAS PT; HOUSE RV; GAWORSKI CL; SHERWOOD RL; LUSTER MI; HAGEN KL; ABDO K; JACKSON CD; ROYCROFT J; ARANYI C;
Indirizzi:
IIT,RES INST,DEPT LIFE SCI,10 W 35TH ST CHICAGO IL 60616 NIEHS,NATL TOXICOL PROGRAM RES TRIANGLE PK NC 27709 UNIV ILLINOIS,HLTH SCI CTR,CTR RES RESOURCES CHICAGO IL 60612 NATL CTR TOXICOL RES JEFFERSON AR 72079
Titolo Testata:
Fundamental and applied toxicology
fascicolo: 2, volume: 27, anno: 1995,
pagine: 177 - 184
SICI:
0272-0590(1995)27:2<177:LVSIOI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYL NITRITE; HOST-RESISTANCE; HOMOSEXUAL MEN; TOXICITY; IMMUNITY; SARCOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H.V. Ratajczak et al., "LOCAL VERSUS SYSTEMIC IMMUNOTOXICITY OF ISOBUTYL NITRITE FOLLOWING SUBCHRONIC INHALATION EXPOSURE OF FEMALE B6C3F1 MICE", Fundamental and applied toxicology, 27(2), 1995, pp. 177-184

Abstract

Female B6C3F1 mice were exposed to isobutyl nitrite (IBN) by inhalation at 0, 37.5, 75, or 150 ppm for 6 hr per day, 5 days per week for 15weeks. The potential of this compound to induce immunotoxicity was assessed during the 3rd, 13th, 14th, and 15th week of exposure and after2 weeks of recovery following the 15 weeks of exposure. Both systemicand lung immune functions were examined, including body and lymphoid organ weights, pulmonary macrophage function and host defense, expression of splenic lymphocyte cell-surface markers, natural killer cell function, mixed lymphocyte reaction, and induction of specific antibody to a T-cell-dependent antigen. There was a dose-related suppression ofT-cell-dependent antibody-forming cell responses in the spleen following IBN exposure; however, other measures of T-cell and nonspecific immunity were not significantly affected. A dose-related increase of H2O2 production by alveolar macrophages was present after 12 but not after 68 exposures to IBN. In contrast, pulmonary host defense mechanisms against Klebsiella pneumoniae were unaffected. These results suggest that in the absence of changes in host resistance, IBN may have selective and partially reversible effects on the immune system. (C) 1995 society of Toxicology

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:38:49