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Titolo:
EFFECTS OF DOPAMINE ON SNAIL NEURONS
Autore:
EMADUDDIN M; LIU GJ; TAKEUCHI H;
Indirizzi:
GIFU UNIV,SCH MED,DEPT PHYSIOL,TSUKASA MACHI 40 GIFU 500 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1-3, volume: 283, anno: 1995,
pagine: 113 - 124
SICI:
0014-2999(1995)283:1-3<113:EODOSN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHATINA-FULICA-FERUSSAC; PUTATIVE NEUROTRANSMITTER SUBSTANCES; GEANT AFRICAN SNAIL; GIANT-NEURONS; LYMNAEA-STAGNALIS; RECEPTOR AGONIST; AXONAL PATHWAYS; CYCLIC-AMP; F 82526; CLONING;
Keywords:
CATECHOLAMINE; DOPAMINE; DOPAMINE RECEPTOR, AGONIST, ANTAGONIST; PROTEIN KINASE INHIBITOR; OUABAIN; IONIC MECHANISM; VOLTAGE CLAMP; NEURON; (SNAIL);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Emaduddin et al., "EFFECTS OF DOPAMINE ON SNAIL NEURONS", European journal of pharmacology, 283(1-3), 1995, pp. 113-124

Abstract

The pharmacological features of dopamine receptors in identifiable giant neurone types of a snail (Achatina fulica Ferussac) were studied. Under voltage clamp, two neurone types, LVMN (left ventral multiple spike neurone) and d-RPeAN (dorsal-right pedal anterior neurone), produced an inward current (I-in) in response to dopamine, (-)-noradrenalineand epinine, whereas v-LCDN (ventral-left cerebral distinct neurone) produced an outward current (I-out) in response to dopamine and epinine. Mammalian dopamine receptor agonists, fenoldopam (dopamine D-1-likereceptor agonist), (+/-)-SKF 38393 enyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol) (D-1-like), apomorphine (D-2-like), (-)-quinpirole (D-3 and D-4) and methylergometrine showed slight or no effect. (+/-)-SKF 83566 o-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1 H-3-benzazepine) (dopamine D-1-like receptor antagonist) and (+)-UH 232 +)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin (D-3 and D-2) non-competitively inhibited the I-in of LVMN and d-RPeAN, but (+/-)-sulpiride (D-2-like) was without effect. In contrast, (+/-)-sulpiride competitively inhibited I-out of v-LCDN, (+)-UH 232 non-competitively inhibited I-out of v-LCDN but (+/-)-SKF 83566 was without effect. H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) (non-selective protein kinase inhibitor) inhibited I-in of LVMN and d-RPeAN, but did not affect I-out of v-LCDN. Dopamine-induced I-in was Na+-dependent; I-out was K+-dependent. Ouabain did not affect these currents. We propose. that the pharmacological features of Achatina neuronal dopamine receptors are not fully comparable to those of mammals, although intracellular signal transduction systems linked with dopamine receptors may similarly exist in different animal species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:25:27