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Titolo:
NOVEL EVIDENCE THAT BETA-ADRENOCEPTORS OF THE MEDIAL SEPTAL AREA REGULATE BLOOD-PRESSURE AND ELECTROLYTE BALANCE
Autore:
SAAD WA; MENANI JV; CAMARGO LAA; ANTUNESRODRIGUES J; SAAD WA;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST BR-14801903ARARAQUARA SP BRAZIL
Titolo Testata:
Life sciences
fascicolo: 17, volume: 57, anno: 1995,
pagine: 1605 - 1611
SICI:
0024-3205(1995)57:17<1605:NETBOT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCRETION; SODIUM; RAT;
Keywords:
SEPTAL AREA; ELECTROLYTE BALANCE; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "NOVEL EVIDENCE THAT BETA-ADRENOCEPTORS OF THE MEDIAL SEPTAL AREA REGULATE BLOOD-PRESSURE AND ELECTROLYTE BALANCE", Life sciences, 57(17), 1995, pp. 1605-1611

Abstract

We investigated the participation of the beta-adrenoceptors of the septal area (SA) in sodium and potassium excretion and urine flow. The alterations in arterial pressure and some renal functions were also investigated. The injection of 2.10(-9) to 16.10(-9)M of isoproterenol, through a cannula permanently implanted into the SA produced a significant dose-dependent decrease in urinary Na+ and K+ excretion and urinary flow. Pretreatment with 16.10(-9) M butoxamine antagonized the effect of 4.10(-9) M isoproterenol but pretreatment with 16.10(-9) M practolol did not abolish the effect of isoproterenol. The beta 2-agonist terbutaline and salbutamol (4.10(-9) M when injected intraseptally also caused a decrease in urine flow and in renal Na+ and K+ excretion. After injection of isoproterenol or salbutamol (4.10(-9) M) into the SA, the arterial pressure, glomerular, filtration rate (GFR) and filtered Nd were reduced while Na+ fractional reabsorption was increased. The results indicate that the beta 2-adrenoceptors of the SA play a role inthe decrease of Na+, K+ and urine flow and this effect may be due to a drop in GFR and filtered Na+ and to the rise in tubular Na+ reabsorption.

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Documento generato il 04/12/20 alle ore 15:40:24