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Titolo:
TIME-COURSE OF ACTION AND INTUBATING CONDITIONS WITH ROCURONIUM BROMIDE UNDER PROPOFOL-ALFENTANIL ANESTHESIA
Autore:
HOFMOCKEL R; BENAD G;
Indirizzi:
UNIV ROSTOCK,SCH MED,ANAESTHESIOL & INTENS THERAPY CLIN O-2500 ROSTOCK GERMANY
Titolo Testata:
European journal of anaesthesiology
, volume: 12, anno: 1995, supplemento:, 11
pagine: 69 - 72
SICI:
0265-0215(1995)12:<69:TOAAIC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Keywords:
NEUROMUSCULAR RELAXANTS, ROCURONIUM; PHARMACOKINETICS, PRIMING; INTUBATION, TRACHEAL; RECOVERY; MEASUREMENT TECHNIQUES, ELECTROMYOGRAPHY, MECHANOMYOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R. Hofmockel e G. Benad, "TIME-COURSE OF ACTION AND INTUBATING CONDITIONS WITH ROCURONIUM BROMIDE UNDER PROPOFOL-ALFENTANIL ANESTHESIA", European journal of anaesthesiology, 12, 1995, pp. 69-72

Abstract

Thirty ASA I and II patients received either an intubating dose of 0.6 mg kg(-1) rocuronium (2 x ED(95), group 1) or 0.06 mg kg(-1) as a priming dose followed by an intubating dose of 0.24 mg kg(-1) rocuronium(group 2) 4 min later. Anaesthesia was induced with propofol (2.0 mg kg(-1)) and alfentanil (0.02 mg kg(-1)) and maintained with nitrous oxide/oxygen and propofol (6.0 mg kg(-1) h(-1)). Neuromuscular function was monitored mechanomyographically and electromyographically with train-of-four (TOF) stimulation at the wrist every 10 s. The following parameters were measured and compared between the two groups: time to 90% block (intubation time), time to maximum block (onset time), and thetimes for T1 (25%, 75% and 90%) and TOF > 70%. In group 1 the intubation time was significantly shorter (40 +/- 10 s) than in group 2 (51 +/- 11 s). Intubating conditions were good or excellent in both groups. The clinical duration of action was 28 +/- 8 min in group 1 and 15 +/- 3 min in group 2, respectively. Mechanomyography showed a significantly faster development of neuromuscular block than electromyography. The comparison of mechanomyographically and electromyographically measured recovery times did not show any differences. In 60% of the patients a priming dose of 0.06 mg kg(-1) was followed by a considerable decrease in neuromuscular function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:35:02