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Titolo:
THE PERSISTENCE OF BEHAVIORAL SENSITIZATION TO COCAINE PARALLELS ENHANCED INHIBITION OF NUCLEUS-ACCUMBENS NEURONS
Autore:
HENRY DJ; WHITE FJ;
Indirizzi:
FUHS,CMS,DEPT NEUROSCI,NEUROPSYCHOPHARMACOL LAB,3333 GREEN BAY RD N CHICAGO IL 60064 FUHS,CMS,DEPT NEUROSCI,NEUROPSYCHOPHARMACOL LAB N CHICAGO IL 60064 UNIV WASHINGTON,SCH MED,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
The Journal of neuroscience
fascicolo: 9, volume: 15, anno: 1995,
pagine: 6287 - 6299
SICI:
0270-6474(1995)15:9<6287:TPOBST>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR STIMULATION ENABLES; EXTRACELLULAR DOPAMINE; TIME COURSE; INDIVIDUAL-DIFFERENCES; REVERSE TOLERANCE; RAT-BRAIN; AMPHETAMINE; EXPRESSION; WITHDRAWAL; MORPHINE;
Keywords:
COCAINE; DOPAMINE; LOCOMOTOR BEHAVIOR; NUCLEUS ACCUMBENS; SENSITIZATION; PSYCHOMOTOR STIMULANT; DRUG WITHDRAWAL; DOPAMINE D1 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Henry e F.J. White, "THE PERSISTENCE OF BEHAVIORAL SENSITIZATION TO COCAINE PARALLELS ENHANCED INHIBITION OF NUCLEUS-ACCUMBENS NEURONS", The Journal of neuroscience, 15(9), 1995, pp. 6287-6299

Abstract

The mesoaccumbens dopamine system is intricately involved in the locomotor stimulation produced by cocaine and sensitization of this effectfollowing repeated cocaine administration. The mechanisms responsiblefor the expression of sensitized locomotion appear to involve alterations in both presynaptic (increased dopamine release) and postsynaptic(increased responsiveness of dopamine D1 receptors) aspects of dopamine neurotransmission within the nucleus accumbens. The present experiments used behavioral and single-cell electrophysiological techniques to determine the persistence of sensitization and of enhanced postsynaptic responses to cocaine within the nucleus accumbens following various periods of withdrawal from repeated cocaine treatment (10 mg/kg i.p., twice daily, 14 d). Behavioral sensitization to the locomotor stimulant effects of cocaine was evident after 1 d, 1 week, and 1 month, butnot 2 months of withdrawal. A similar time course was observed for the enhanced efficacy of cocaine-induced inhibition of nucleus accumbensneurons, whether cocaine was administered systemically or locally by microiontophoresis. Nucleus accumbens neurons also exhibited sensitized inhibitory responses to iontophoretically applied GABA after 1 d of withdrawal, but not later times. These findings suggest that cocaine sensitization is relatively persistent, but not necessarily permanent, and support the hypothesis that expression of behavioral sensitizationto cocaine involves actions within the NAc, particularly those mediated by dopamine D1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:18:00