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Titolo:
PULSATILE ADRENOCORTICOTROPIC HORMONE - AN OVERVIEW
Autore:
GUDMUNDSSON A; CARNES M;
Indirizzi:
WILLIAM S MIDDLETON MEM VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,ROOM B-2091 MADISON WI 53705 WILLIAM S MIDDLETON MEM VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN MADISON WI 53705 UNIV WISCONSIN,DEPT MED MADISON WI 00000
Titolo Testata:
Biological psychiatry
fascicolo: 3, volume: 41, anno: 1997,
pagine: 342 - 365
SICI:
0006-3223(1997)41:3<342:PAH-AO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; MELANOCYTE-STIMULATING HORMONE; INSULIN-INDUCED HYPOGLYCEMIA; PITUITARY VENOUS EFFLUENT; MAJOR DEPRESSIVE-ILLNESS; ARGININE-VASOPRESSIN; CORTISOL SECRETION; PLASMA ADRENOCORTICOTROPIN; ADRENAL AXIS; NORMAL MEN;
Keywords:
HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; CORTICOTROPIN; ULTRADIAN; CIRCADIAN; PULSATILITY AND PERIODICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
A. Gudmundsson e M. Carnes, "PULSATILE ADRENOCORTICOTROPIC HORMONE - AN OVERVIEW", Biological psychiatry, 41(3), 1997, pp. 342-365

Abstract

Adrenocorticotropic hormone (ACTH) is secreted by corticotrophic cells in pulsatile bursts. This paper reviews the extant literature on thephenomenon of phenomenon of pulsatile. ACTH after addressing basic issues of hormone pulsatility in neuroendocrine systems. The following themes emerged from reviewing 51 studies measuring plasma ACTH at intervals of 20 min or less: marked inter-individual variability in the pattern of ACTH, the dependence of pulse identification on sampling frequency, the similarity in ACTH pulse amplitude and frequency across species, and rite predominance of amplitude over frequency changes in ACTHpulses in altered physiological states. As the hypothalamic-pituitary-adrenocortical (HPA) axis plays a critical role in orchestrating adaptation and survival, the ability to modulate the shape of ACTH signalsmay prove to be an important means of transmitting complex information, to ACTH responsive cells. The clinical and neurobiological significance of temporal alterations in ACTH secretion represents an area for future investigation. (C) 1997 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:09:14