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Titolo:
RANDOMIZED COMPARISON OF REACTOGENICITY AND IMMUNOGENICITY OF 2 WHOLE-CELL PERTUSSIS VACCINES
Autore:
STEINHOFF MC; REED GF; DECKER MD; EDWARDS KM; ENGLUND JA; PICHICHERO ME; RENNELS MB; ANDERSON EL; DELORIA MA; MEADE BD;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT INT HLTH,624 N BROADWAY,ROOM 125 BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT BALTIMORE MD 21205 NIAID,DIV MICROBIOL & INFECT DIS BETHESDA MD 20892 VANDERBILT UNIV,SCH MED,DEPT PREVENT MED NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT MED INFECT DIS NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT PEDIAT NASHVILLE TN 37212 BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL HOUSTON TX 77030 BAYLOR COLL MED,DEPT PEDIAT HOUSTON TX 77030 UNIV ROCHESTER,SCH MED,DEPT PEDIAT ROCHESTER NY 14642 UNIV MARYLAND,SCH MED,DEPT PEDIAT BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,CTR VACCINE DEV BALTIMORE MD 21201 ST LOUIS UNIV,SCH MED,DEPT MED ST LOUIS MO 63104 US FDA,CTR DRUG EVALUAT & RES,DIV BACTERIAL PROD ROCKVILLE MD 20857
Titolo Testata:
Pediatrics
fascicolo: 3, volume: 96, anno: 1995, supplemento:, S
pagine: 567 - 570
SICI:
0031-4005(1995)96:3<567:RCORAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY-RESPONSE; ADVERSE REACTIONS; DIPHTHERIA; ANTIGENS; DTP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Steinhoff et al., "RANDOMIZED COMPARISON OF REACTOGENICITY AND IMMUNOGENICITY OF 2 WHOLE-CELL PERTUSSIS VACCINES", Pediatrics, 96(3), 1995, pp. 567-570

Abstract

Objective. To compare prospectively the reactogenicity and immunogenicity of two licensed whole-cell pertussis vaccines. Methods. We conducted a prospective, randomized, double-blinded assessment of two licensed whole-cell pertussis vaccines with diphtheria and tetanus toxoids that were included in a multicenter trial evaluating 13 acellular pertussis vaccines. Infants were immunized at 2, 4, and 6 months of age with a single lot of Lederle (309 infants) or Massachusetts Public HealthBiologic Laboratories (MPHBL; 94 infants) vaccine. Results. The groupreceiving the Lederle vaccine demonstrated significantly higher antibody titers to pertussis toxin by enzyme-linked immunosorbent assay (ELISA) and by the Chinese hamster ovary cell pertussis toxin neutralization assay, and to fimbrial antigens by ELISA, as well as higher mean agglutinin titers. In contrast, the group receiving the MPHBL vaccine demonstrated higher ELISA antibody levels to filamentous hemagglutinin and pertactin. Similar differences were observed in the proportions ofvaccinees seroconverting to these antigens. Rates of systemic and local reactions were relatively low for both vaccines. Although the Lederle product had substantially lower reactogenicity in this study than previously reported for that vaccine, the MPHBL vaccine was significantly less reactogenic in nearly all clinical categories. Conclusion. Thetwo whole-cell vaccines demonstrated statistically significant differences in postimmunization antibody levels to all six evaluated pertussis antigens. Whether these statistically significant differences in antibody levels have clinical relevance is not clear. Rates of nearly all local and systemic reactions were significantly lower among the MPHBL group than the Lederle group. Licensed whole-cell diphtheria-tetanus-pertussis vaccines produced by different manufacturers cannot be assumed to be similar in reactogenicity or immunogenicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:31:59