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Titolo:
AEROSOLIZED INTERFERON-GAMMA FOR MYCOBACTERIUM AVIUM-COMPLEX LUNG-DISEASE
Autore:
CHATTE G; PANTEIX G; PERRINFAYOLLE M; PACHECO Y;
Indirizzi:
CTR HOSP LYON SUD,SERV PNEUMOL F-69495 PIERRE BENITE FRANCE CTR HOSP LYON SUD,SERV PNEUMOL F-69495 PIERRE BENITE FRANCE INST PASTEUR LYON FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 3, volume: 152, anno: 1995,
pagine: 1094 - 1096
SICI:
1073-449X(1995)152:3<1094:AIFMAL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
G. Chatte et al., "AEROSOLIZED INTERFERON-GAMMA FOR MYCOBACTERIUM AVIUM-COMPLEX LUNG-DISEASE", American journal of respiratory and critical care medicine, 152(3), 1995, pp. 1094-1096

Abstract

It has recently been shown that human alveolar macrophages tan be selectively activated without systemic effect by the use of aerosolized interferon-gamma (IFN gamma), a cytokine that enhances macrophage oxidative and antimicrobial activity. We report the case of a 38-yr-old mannegative for human immunodeficiency virus (HIV), with silicosis and advanced cavitary lung disease due to Mycobacterium avium intracellulare (MAI), who failed to improve despite 3 yr of continuous medical therapy with three or more drugs. He received three courses of aerosolizedIFN gamma (500 mu g 3 d per week for 5 wk in two courses and 200 mu g3 d a week for 5 wk after a short single trial of subcutaneous IFN gamma). The numbers of MAI decreased in the sputum during therapy, but cultures of the organism remained positive at the same level for the first two treatment periods. The patient's sputum became AFB smear negative and the number of colonies decreased significantly after the thirdcourse of IFN gamma therapy. Cessation of lFN gamma was associated with a rapid increase in the numbers of MAI in the sputum. Aerosolized IFN gamma can be considered as an adjuvant to conventional drug therapy, with a good tolerance, in cases of lung disease caused by resistant MAI.

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Documento generato il 26/11/20 alle ore 19:34:31