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Titolo:
MALIGNANT MESOTHELIOMA OF THE PLEURA - INTEROBSERVER VARIABILITY
Autore:
ANDRION A; MAGNANI C; BETTA PG; DONNA A; MOLLO F; SCELSI M; BERNARDI P; BOTTA M; TERRACINI B;
Indirizzi:
CITY HOSP,DIV ANAT PATHOL,VIA BOTALLO 4 I-14100 ASTI ITALY LOCAL HLTH AUTHOR,CANC EPIDEMIOL UNIT TURIN ITALY LOCAL HLTH AUTHOR,DIV ANAT PATHOL TURIN ITALY UNIV TURIN TURIN ITALY SANTO SPIRITO HOSP,DIV ANAT PATHOL CASALE MONFERRATO ITALY SANTO SPIRITO HOSP,SPECIAL PROJECT ASBESTOS CEMENT CASALE MONFERRATO ITALY LOCAL HLTH AUTHOR CASALE MONFERRATO ITALY CITY HOSP,DIV ANAT PATHOL ALESSANDRIA ITALY UNIV PAVIA,DIV ANAT PATHOL PAVIA ITALY
Titolo Testata:
Journal of Clinical Pathology
fascicolo: 9, volume: 48, anno: 1995,
pagine: 856 - 860
SICI:
0021-9746(1995)48:9<856:MMOTP->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSERVER VARIABILITY; HIGH AGREEMENT; LOW KAPPA; DIAGNOSIS; PANEL; PARADOXES; CANCER; TUMORS;
Keywords:
MALIGNANT MESOTHELIOMA; PATHOLOGY PANEL; INTEROBSERVER VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Andrion et al., "MALIGNANT MESOTHELIOMA OF THE PLEURA - INTEROBSERVER VARIABILITY", Journal of Clinical Pathology, 48(9), 1995, pp. 856-860

Abstract

Aims-To assess the consistency of histopathological diagnosis of pleural malignant mesothelioma by estimating interobserver agreement between five pathologists. Methods-Eighty eight histological sets pertaining to original diagnoses of pleural malignant mesothelioma were reviewed separately by each pathologist. Diagnostic likelihood was graded as definite (A), probable (B), possible (C), improbable (D), and definitely not (E) malignant mesothelioma. The following indexes were estimated: observed proportion of agreement (Po), kappa statistics and proportion of agreement for ''positive'' (Ppos) and ''negative'' (Pneg) diagnoses. Results-Sixty cases (68.2%) were rated by at least three reviewers as A or E and by none of the others as D or E. Five (5.7%) were rated by at least two reviewers as D or E and by none of the others as A or E. Nine (10.2%) showed a serious disagreement, rated A or B and D or E. Agreement for sets obtained at necropsy/surgery (median kappa w=0.57) was similar to that for endoscopic material (median kappa w=0.54). Agreement was poor on material obtained by needle biopsy (median kappa w=0.21). The median value of Ppos varied between 0.94 (necropsy/surgery) and 0.67 (needle biopsy) and that of Pneg between 0.78 (necropsy/surgery) and 0.34 (unspecified biopsy). Interobserver agreement on histological typing was good overall (median kappa=0.59). Conclusions-Ofthe original histological diagnoses, 70% were consistently reproducedthrough panel review. Most indexes of agreement between pathologists ranged from poor (needle biopsy) to moderate (necropsy/surgery). Agreement in confirming malignant mesothelioma was greater than that regarding exclusion of this diagnosis. Of the cases finally considered to have malignant mesothelioma, the reproducibility of histological typing was relatively satisfactory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:30:54