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Titolo:
HOW SYMPATHETIC TONE MAINTAINS OR ALTERS ARTERIAL-PRESSURE
Autore:
JULIEN C; ZHANG ZQ; BARRES C;
Indirizzi:
FAC PHARM LYON,DEPT PHYSIOL & PHARMACOL CLIN,CNRS,URA 1483,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE
Titolo Testata:
Fundamental and clinical pharmacology
fascicolo: 4, volume: 9, anno: 1995,
pagine: 343 - 349
SICI:
0767-3981(1995)9:4<343:HSTMOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL VASCULAR-RESPONSES; BLOOD-PRESSURE; SPECTRAL-ANALYSIS; HEART-RATE; CARDIOVASCULAR VARIABILITY; DENERVATED RATS; CONSCIOUS RATS; SYSTEM; STRESS; LABILITY;
Keywords:
ARTERIAL BARORECEPTOR REFLEX; ARTERIAL PRESSURE VARIABILITY; SYMPATHETIC NERVOUS SYSTEM; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
C. Julien et al., "HOW SYMPATHETIC TONE MAINTAINS OR ALTERS ARTERIAL-PRESSURE", Fundamental and clinical pharmacology, 9(4), 1995, pp. 343-349

Abstract

After chronic sympathectomy or sinoaortic denervation (SAD), arterialpressure (AP) becomes extremely unstable, especially because of movement-related depressor episodes. The simultaneous measurement of AP andregional blood flows in sympathectomized and SAD rats indicates that these depressor episodes are accompanied by strong regional vasodilations, possibly involving an autoregulatory component. The sympathetic nervous system, mainly through baroreflex modulation of its activity, overrides these responses and thereby, considerably limits the AP variability. In the conscious unrestrained rat, AP fluctuates in a narrow range (variation coefficients calculated over 1-hour beat-to-beat recordings are typically similar to 5%). This variability of AP involves sympathetically-mediated presser episodes that are coupled to behavior and alerting environmental stimuli. Regarding the latter, studies in SAD rats point to an opposing interaction between centrally-induced sympathoexcitation and baroreflex activation. Another component of normal AP variability appears as an oscillation centered around 0.4 Hz. Spectral analysis of AP and regional hemodynamic variables indicates that this oscillation is secondary to rhythmic fluctuations in the vasomotorsympathetic tone that are synchronized by the arterial baroreceptor reflex. It is concluded that both stability and normal variability of AP critically depend on the baroreflex control of the sympathetic vascular tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:49:12