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Titolo:
THE EFFECTS OF TRANSPLANTATION OF HEPATOCYTES CULTURED WITH INSULIN ON ACUTE LIVER-FAILURE INDUCED BY 90-PERCENT HEPATECTOMY IN THE RAT
Autore:
WANG XD; ZHAO XD; ANDERSSON R;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN EIGHT HOSP HARBIN HARBIN PEOPLES R CHINA
Titolo Testata:
The European journal of surgery
fascicolo: 7, volume: 161, anno: 1995,
pagine: 475 - 481
SICI:
1102-4151(1995)161:7<475:TEOTOH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASSIVE HEPATIC-NECROSIS; KUPFFER CELLS;
Keywords:
ACUTE LIVER FAILURE; HEPATECTOMY; HEPATOCYTES; TRANSPLANTATION; INSULIN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
X.D. Wang et al., "THE EFFECTS OF TRANSPLANTATION OF HEPATOCYTES CULTURED WITH INSULIN ON ACUTE LIVER-FAILURE INDUCED BY 90-PERCENT HEPATECTOMY IN THE RAT", The European journal of surgery, 161(7), 1995, pp. 475-481

Abstract

Objective: To evaluate the influence of transplantation of hepatocytes either not cultured or cultured with or without insulin on survival in rats with acute liver failure induced by 90% hepatectomy. Design: Randomized laboratory experiment. Setting: University department, Sweden. Material: 60 Adult male Sprague-Dawley rats, not including donors. Interventions: 90% hepatectomy without hepatocyte transplantation, or with intrasplenic transplantation of: uncultured hepatocytes immediately after resection, or uncultured hepatocytes one or three days beforeresection, or hepatocytes cultured with or without insulin immediately after resection (n = 10 in each group). Main outcome measures: Cell viability, attachment ability, survival, liver function, and body weight. Results: Transplantation of hepatocytes cultured for 3 days without insulin or of uncultured hepatocytes one day prior to hepatectomy did not significantly improve 30-day survival compared with uncultured hepatocyte transplantation immediately after hepatectomy. Hepatocytes cultured with insulin for 3 days and transplanted immediately after hepatectomy significantly improved survival compared with animals in which hepatocytes were transplanted either uncultured or cultured for 3 days without insulin immediately after hepatectomy. Hepatocyte transplantation 3 days before hepatectomy further increased survival compared with the other groups in which transplantation was done immediately after hepatectomy. Acute failure, acute compensatory, and late 'enhanced'phases were defined within 30 days of hepatectomy. Conclusion: Transplantation of hepatocytes that are cultured with hepatocellular trophicfactors (for example insulin) before transplantation may have the potential to increase the effectiveness of transplanted hepatocytes in the treatment of acute liver failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:57:00