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Titolo:
DIFFERENTIAL-DIAGNOSIS OF HURTHLE CELL NEOPLASMS ON FINE-NEEDLE ASPIRATES - CAN WE DO ANY BETTER WITH MORPHOMETRY
Autore:
PAMBUCCIAN SE; BECKER RL; ALI SZ; SAVIK K; ROSENTHAL DL;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,DIV QUANTITAT PATHOL WASHINGTON DC 20306 ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,DIV QUANTITAT PATHOL WASHINGTON DC 20306 JOHNS HOPKINS MED INST,DEPT PATHOL,DIV CYTOPATHOL BALTIMORE MD 21205 UNIV MINNESOTA,SCH MED,DEPT THORAC TRANSPLANT MINNEAPOLIS MN 55455 UNIV MINNESOTA,DEPT PATHOL MINNEAPOLIS MN 55455
Titolo Testata:
Acta cytologica
fascicolo: 1, volume: 41, anno: 1997,
pagine: 197 - 208
SICI:
0001-5547(1997)41:1<197:DOHCNO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE NUCLEOLAR FEATURES; THYROID-GLAND; FOLLICULAR NEOPLASMS; IMAGE-ANALYSIS; NUCLEAR-DNA; TUMORS; LESIONS; CARCINOMA; CLASSIFICATION; FLOW;
Keywords:
THYROID NEOPLASMS; ASPIRATION BIOPSY; MORPHOMETRY; NUCLEOLUS; HURTHLE CELL (OXYPHILIC) NEOPLASMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Pambuccian et al., "DIFFERENTIAL-DIAGNOSIS OF HURTHLE CELL NEOPLASMS ON FINE-NEEDLE ASPIRATES - CAN WE DO ANY BETTER WITH MORPHOMETRY", Acta cytologica, 41(1), 1997, pp. 197-208

Abstract

OBJECTIVE: To determine the value of computerized interactive morphometry in the preoperative prediction of malignancy in fine needle aspirates of Hurthle cell neoplasms. STUDY DESIGN: Alcohol-fixed, Papanicolaou-stained fine needle aspiration smears of histologically proven Hurthle cell adenomas (HCA) (n=10) and Hurthle cell carcinomas (HCC) (n=9) were studied by interactive computerized morphometry. The measured features included the areas, perimeters and shape factors of individualcells, nuclei and nucleoli; the nucleocytoplasmic and nucleolonuclearratios; and the eccentricities of nuclei and nucleoli. RESULTS: Only nucleolar features showed statistically signficant differences betweenHCA and HCC. These features were the nucleolar area and its standard deviation, the nucleolar form factor and circularity, and the nucleolonuclear ratio. The most effective, albeit imperfect, discrimination was achieved by the nucleolar form factor. CONCLUSION: Nucleolar features, such as size, variation in size and roundness, may be more effective than cellular or nuclear features in differentiating between HCA andHCC in fine needle aspiration smears.

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Documento generato il 30/10/20 alle ore 09:05:03