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Titolo:
EPITOPE REPERTOIRE OF HUMAN CD4(-CELLS ON TETANUS TOXIN - IDENTIFICATION OF IMMUNODOMINANT SEQUENCE SEGMENTS() T)
Autore:
DIETHELMOKITA BM; RAJU R; OKITA DK; CONTIFINE BM;
Indirizzi:
UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN55108 UNIV MINNESOTA,COLL BIOL SCI,DEPT BIOCHEM ST PAUL MN 55108 UNIV MINNESOTA,SCH MED,DEPT PHARMACOL MINNEAPOLIS MN 55455
Titolo Testata:
The Journal of infectious diseases
fascicolo: 2, volume: 175, anno: 1997,
pagine: 382 - 391
SICI:
0022-1899(1997)175:2<382:EROHCO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ALPHA-SUBUNIT; MHC-CLASS-II; MUSCLE ACETYLCHOLINE-RECEPTOR; MYASTHENIA-GRAVIS; PROMISCUOUS RECOGNITION; SYNTHETIC PEPTIDES; CRYSTAL-STRUCTURE; LIGHT-CHAIN; IMMUNOGENICITY; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Diethelmokita et al., "EPITOPE REPERTOIRE OF HUMAN CD4(-CELLS ON TETANUS TOXIN - IDENTIFICATION OF IMMUNODOMINANT SEQUENCE SEGMENTS() T)", The Journal of infectious diseases, 175(2), 1997, pp. 382-391

Abstract

Sequence regions of tetanus toxin-forming CD4(+) cell epitopes in 8 HLA-disparate subjects were identified. Overlapping synthetic peptides corresponding to the complete tetanus toxin sequence were used to test, in a proliferation assay, unselected blood CD4(+) cells or CD4(+) cell lines propagated by stimulation with tetanus toroid, The CD4(+) cell lines recognized most peptides recognized by the blood CD4(+) cells and they recognized additional peptides, Their responses were strongerthan those of unselected blood CD4(+) cells, Two peptides were recognized by all subjects: one largely overlapped a tetanus toxin sequence region previously identified as a ''universal'' T cell epitope, Thirteen other peptides elicited a CD4(+) cell response in 6 or 7 of the 8 subjects, and another 10 elicited responses in 5 subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:27:07