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Titolo:
PHARMACOLOGY OF METABOTROPIC GLUTAMATE RECEPTOR-MEDIATED ENHANCEMENT OF RESPONSES TO EXCITATORY AND INHIBITORY AMINO-ACIDS ON RAT SPINAL NEURONS IN-VIVO
Autore:
BOND A; LODGE D;
Indirizzi:
LILLY RES CTR LTD,ERL WOOD MANOR WINDLESHAM GU20 6PH SURREY ENGLAND LILLY RES CTR LTD WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 8, volume: 34, anno: 1995,
pagine: 1015 - 1023
SICI:
0028-3908(1995)34:8<1015:POMGRE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL PHOSPHOLIPID-METABOLISM; CENTRAL NERVOUS-SYSTEM; IONOTROPIC GLUTAMATE; HIPPOCAMPAL-NEURONS; SIGNAL-TRANSDUCTION; PHOSPHATE FORMATION; BRAIN-FUNCTION; AGONIST; TRANSMITTERS; POTENTIATION;
Keywords:
(1S,3R)-1-AMINOCYCLO-PENTANE-1,3-DICARBOXYLATE (1S,3R-ACPD); ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE (AMPA); N-METHYL-D-ASPARTATE (NMDA); GLYCINE; METABOTROPIC GLUTAMATE RECEPTORS (MGLURS); SPINAL CORD; EXCITATORY AMINO ACIDS; INHIBITORY AMINO ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Bond e D. Lodge, "PHARMACOLOGY OF METABOTROPIC GLUTAMATE RECEPTOR-MEDIATED ENHANCEMENT OF RESPONSES TO EXCITATORY AND INHIBITORY AMINO-ACIDS ON RAT SPINAL NEURONS IN-VIVO", Neuropharmacology, 34(8), 1995, pp. 1015-1023

Abstract

Using the technique of microelectrophoresis on spinal neurones in pentobarbitone-anaesthetized rats, (1S,3R)-1-aminocyclo-pentane-1,3-dicarboxylate (1S,3R-ACPD) reversibly and dose-dependently enhanced responses to pha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), kainate, N-methyl-D-aspartate (NMDA) and L-glutamate to a similar extent. 1S,3R-ACPD also enhanced inhibitory responses to both glycine and gamma-aminobutyrate (GABA). Such results are consistent with a metabotropicglutamate receptor-mediated decrease in membrane conductance. 1S,3R-ACPD was the most active metabotropic agonist tested for these effects;the rank order of activity was: 1S,3R-ACPD greater than or equal to (2S,3S,4S)alpha-(carboxycyclopropyl)-glycine(L - CCG - 1) > (R,S)-3,5-dihydroxy-phenylglycine (3,5 - DHPG) > (S)-homoquisqualate > quisqualate = 1S,3S-ACPD > L-2-amino-4-phosphonobutyrate (L-AP4)> 1R,3S-ACPD. These effects of 1 S,3R-ACPD were antagonized by (RS)-alpha-methyl-4-carboxy-phenylglycine (M4CPG) and (S)-4-carboxy-3-hydroxy-phenylglycine (4C3HPG) but not by (S)-4-carboxy-phenylglycine (4CPG) or L-amino-3-phosphono-propionate (L-AP3). The pharmacology of the actions of mGluR agonists and antagonists on rat spinal neurones in vivo does not obviously correlate with the published pharmacology of a single cloned metabotropic glutamate receptor subtype but rather suggests that bath Group 1 and 2 receptors contribute to the above effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:26:40