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Titolo:
LIQUID-CHROMATOGRAPHIC ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRIC ANALYSIS OF GLYCINE CONJUGATES AND URINARY ISOVALERYLGLYCINE IN ISOVALERIC ACIDEMIA
Autore:
ITO T; KIDOUCHI K; SUGIYAMA N; KAJITA M; CHIBA T; NIWA T; WADA Y;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PEDIAT,MIZUHO KU NAGOYA AICHI 467 JAPAN NAGOYA CITY HIGASHI GEN HOSP,DEPT PEDIAT NAGOYA AICHI JAPAN NAGOYA UNIV,BRANCH HOSP,DEPT PEDIAT NAGOYA AICHI 466 JAPAN NAGOYA CITY UNIV,FAC PHARMACEUT SCI,DEPT HYGIEN CHEM NAGOYA AICHI 467JAPAN NAGOYA UNIV,BRANCH HOSP,DEPT CLIN LAB NAGOYA AICHI 466 JAPAN
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 2, volume: 670, anno: 1995,
pagine: 317 - 322
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-CARNITINE; IDENTIFICATION; DEFICIENCY; THERAPY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Ito et al., "LIQUID-CHROMATOGRAPHIC ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRIC ANALYSIS OF GLYCINE CONJUGATES AND URINARY ISOVALERYLGLYCINE IN ISOVALERIC ACIDEMIA", Journal of chromatography B. Biomedical applications, 670(2), 1995, pp. 317-322

Abstract

n-Acetylglycine, n-propionylglycine, n-butyrylglycine, isobutyrylglycine, n-valerylglycine, isovalerylglycine, heptanoylglycine, phenylacetylglycine and isovalerylglucuronide were identified based on their liquid chromatographic-atmospheric pressure chemical ionization mass spectra (LC-APCI-MS). We were able to detect the presence of urinary isovalerylglycine in two cases of isovaleric acidemia using LC-APCI-MS. Membrane-filtered urine samples were injected into the LC-APCI-MS system in the negative-ion mode without any further pretreatment, and large amounts of isovalerylglycine were detected as the [M-H](-) ion. The urinary excretion of isovalerylglycine appeared to increase after L-carnitine therapy. This analytical method is quick and easy and it may be auseful tool in understanding dysfunctional conditions in isovaleric acidemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:35:44