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Titolo:
EFFECTS OF ACUTE CAFFEINE INGESTION AND MENOPAUSE ON SULFATE HOMEOSTASIS IN WOMEN
Autore:
BENINCOSA LJ; SAGAWA K; MASSEY LK; MORRIS ME;
Indirizzi:
SUNY BUFFALO,SCH PHARM,DEPT PHARMACEUT,527 HOCHSTETTER HALL AMHERST NY 14260 SUNY BUFFALO,SCH PHARM,DEPT PHARMACEUT AMHERST NY 14260 WASHINGTON STATE UNIV,DEPT FOOD SCI & HUMAN NUTR SPOKANE WA 00000
Titolo Testata:
Life sciences
fascicolo: 16, volume: 57, anno: 1995,
pagine: 1497 - 1505
SICI:
0024-3205(1995)57:16<1497:EOACIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC SULFATE; DIETARY CAFFEINE; HEPARAN-SULFATE; EXCRETION; RAT; PROTEIN;
Keywords:
SULFATE; POSTMENOPAUSE; CAFFEINE; RENAL CLEARANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Benincosa et al., "EFFECTS OF ACUTE CAFFEINE INGESTION AND MENOPAUSE ON SULFATE HOMEOSTASIS IN WOMEN", Life sciences, 57(16), 1995, pp. 1497-1505

Abstract

Inorganic sulfate is a physiological anion which is utilized in the metabolism of both endogenous compounds and xenobiotics. Its homeostasis is maintained predominantly by facilitated reabsorptive processes inthe kidneys. The objectives of the present investigation were to evaluate the effects of menopausal status and caffeine ingestion on the serum concentrations and clearance of inorganic sulfate. Thirty-nine women who were classified as premenopausal, postmenopausal with or without estrogen treatment, and postmenopausal with osteoporosis participated in the study. The women were studied on two separate occasions following the ingestion of a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine was added. All women were habitual caffeine users (mean ingestion of 588 mg caffeine per day) but abstainedfrom all caffeine sources for 2 weeks prior to the control study day. Postmenopausal women with estrogen supplementation exhibited significantly lower sulfate serum concentrations (0.24 +/- 0.02 mM vs. 0.32 +/- 0.04 mM in premenopausal women, mean +/- SD, p<0.05) and a decreasedrenal reabsorption of sulfate for the control (no caffeine) period. There was no difference in serum sulfate or sulfate reabsorption in estrogen supplemented postmenopausal women, compared with women not taking estrogen. Postmenopausal women with osteoporosis had significantly lower creatinine and sulfate clearances than postmenopausal women with estrogen supplementation which may be related to their older age, or factors related to the disease process. The 6 mg/kg dose of caffeine caused a diuresis, but no change in GFR, as indicated by urine volume and creatinine clearance values, respectively. Caffeine administration resulted in an increase in the sulfate excretion rate; there was no change in sulfate serum concentrations. The results of this investigationindicate that menopause results in decreased sulfate serum concentrations that may be the consequence of a decreased renal reabsorption of sulfate. Secondly, this investigation demonstrated that caffeine ingestion increases the urinary excretion of sulfate, an effect that may berelated to the diuretic effect of caffeine or due to a caffeine-induced alteration in the renal reabsorption of sulfate.

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Documento generato il 07/07/20 alle ore 12:33:49