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Titolo:
SYNERGISTIC EFFECTS OF GROWTH-FACTORS ON THE REGULATION OF SMOOTH-MUSCLE CELL SCAVENGER RECEPTOR ACTIVITY
Autore:
GONG QQ; PITAS RE;
Indirizzi:
UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,CARDIOVASC RESINST,POB 419100 SAN FRANCISCO CA 94141 UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,CARDIOVASC RESINST SAN FRANCISCO CA 94141 UNIV CALIF SAN FRANCISCO,DEPT PATHOL SAN FRANCISCO CA 94141
Titolo Testata:
The Journal of biological chemistry
fascicolo: 37, volume: 270, anno: 1995,
pagine: 21672 - 21678
SICI:
0021-9258(1995)270:37<21672:SEOGOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; CHOLESTEROL DEPOSITION; INTERFERON-GAMMA; LYSINE RESIDUES; E-APOPROTEIN; FOAM CELLS; C-FMS; ATHEROSCLEROSIS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
Q.Q. Gong e R.E. Pitas, "SYNERGISTIC EFFECTS OF GROWTH-FACTORS ON THE REGULATION OF SMOOTH-MUSCLE CELL SCAVENGER RECEPTOR ACTIVITY", The Journal of biological chemistry, 270(37), 1995, pp. 21672-21678

Abstract

Rabbit smooth muscle cells (SMC) express types I and II scavenger receptors (ScR) that are up-regulated by platelet secretion products. In the current studies we investigated the effect of growth factors secreted by platelets on ScR activity in rabbit and human SMC. Platelet-derived growth factor (PDGrF BB) and transforming growth factor beta(1) (TGF-beta(1)) at 10 ng/ml increased ScR activity in rabbit SMC (by approximately 4- and 2-fold, respectively) but not in human SMC. Epidermalgrowth factor (EGF) or insulin-like growth factor I (IGF-I) alone hadlittle effect on SMC ScR activity. The growth factors had synergisticeffects on ScR activity and on types I and Il ScR mRNA expression. Inrabbit SMC, PDGF BB, EGF, and TGF-beta(1) together stimulated ScR activity 12-fold. In human SMC, EGF and TGF-beta(1), together with eitherIGF-I or PDGF BB, stimulated receptor activity approximately 7-fold. Growth factor-mediated induction of ScR activity in rabbit and human SMC was blocked by the tyrosine kinase inhibitor tyrphostin 47, whereasthe induction of ScR activity in rabbit but not human SMC was blockedby the protein kinase C inhibitor MDL.29,152. Studies using neutralizing antibodies demonstrated that TGF-beta(1) is the predominant factorin in vitro preparations of platelet secretory products which regulates ScR activity. The growth factors that act synergistically in regulating ScR activity in vitro are all present in atherosclerotic lesions,where they are produced by macrophages, endothelial cells, SMC, and platelets. The data suggest that these growth factors may regulate ScR activity in SMC in vivo and contribute to foam cell formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 23:37:36