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Titolo:
HEART-FAILURE WITH NORMAL SYSTOLIC FUNCTION - A COMMON DISORDER IN OLDER-PEOPLE
Autore:
TRESCH DD; MCGOUGH MF;
Indirizzi:
MED COLL WISCONSIN,DEPT MED,8700 W WISCONSIN AVE MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT CARDIOL & GERIATR MILWAUKEE WI 53226
Titolo Testata:
Journal of the American Geriatrics Society
fascicolo: 9, volume: 43, anno: 1995,
pagine: 1035 - 1042
SICI:
0002-8614(1995)43:9<1035:HWNSF->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR DIASTOLIC FUNCTION; CORONARY-ARTERY DISEASE; ACUTE PULMONARY-EDEMA; ELDERLY PATIENTS; HYPERTROPHIC CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; DOPPLER ECHOCARDIOGRAPHY; ESSENTIAL-HYPERTENSION; PRESSURE OVERLOAD; CARDIAC-HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
D.D. Tresch e M.F. Mcgough, "HEART-FAILURE WITH NORMAL SYSTOLIC FUNCTION - A COMMON DISORDER IN OLDER-PEOPLE", Journal of the American Geriatrics Society, 43(9), 1995, pp. 1035-1042

Abstract

OBJECTIVE: To review the incidence, pathophysiology, significance, diagnosis, and treatment of heart failure with normal systolic function in older patients. DATA SOURCE: Scientific reports of diastolic ventricular dysfunction in both the general population and the geriatric population were identified from repeated searches of the MEDLINE databaseand citations from appropriate articles. STUDY SELECTION: Studies were included only if they demonstrated proper methodology, were from a reputable source, and were published in a peer-reviewed journal. DATA EXTRACTION AND SYNTHESIS: Relevant data were obtained from the articles, with special importance placed on studies designed to examine older patients exclusively or as part of a subgroup in a larger study. Emphasis was placed on data pertaining to the pathophysiology, prognosis, and diagnosis of patients with diastolic dysfunction compared with normals and patients with systolic dysfunction as an etiology of heart failure. Therapeutic interventions were selected for the presence of prospective data with concrete end points such as mortality, functional class, exercise capacity, and regression of left ventricular hypertrophy. CONCLUSION: Diastolic ventricular dysfunction is a significant problem in older people, with at least 40% of older heart failure patients having diastolic dysfunction as the etiology of their heart failure. The pathophysiology of diastolic dysfunction is varied but usually involves impaired left ventricular relaxation and/or increased ventricularstiffness, each partially related to normal aging changes, as well asunderlying cardiovascular diseases. The significance of heart failurecaused by diastolic dysfunction is great, with increased morbidity and mortality compared with other cardiac diseases that have the same preserved systolic function. Diagnosis of diastolic dysfunction can be clinically difficult and often requires further testing to determine ifdiastolic dysfunction is present. At this time, no therapy specifically treats diastolic dysfunction, but several medications, such as diuretics, calcium channel blockers, beta blockers, and angiotension-converting enzyme inhibitors, offer symptomatic relief and may prevent progression of the disorder.

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Documento generato il 07/07/20 alle ore 22:10:56