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Titolo:
ATHEROSCLEROSIS IN THE HUMAN BRACHIAL-ARTERY
Autore:
SORENSEN KE; KRISTENSEN IB; CELERMAJER DS;
Indirizzi:
SKEJBY UNIV HOSP,DEPT CARDIOL DK-8200 AARHUS N DENMARK SKEJBY HOSP,DEPT CARDIOL AARHUS DENMARK AARHUS UNIV,INST FORENS MED AARHUS DENMARK ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL SYDNEY NSW AUSTRALIA
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 2, volume: 29, anno: 1997,
pagine: 318 - 322
SICI:
0735-1097(1997)29:2<318:AITHB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; FOREARM RESISTANCE VESSELS; AMERICAN-HEART-ASSOCIATION; CIGARETTE-SMOKING; CORONARY-ARTERIES; VASCULAR-LESIONS; RISK-FACTORS; HYPERCHOLESTEROLEMIA; VASODILATION; ARTERIOSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Sorensen et al., "ATHEROSCLEROSIS IN THE HUMAN BRACHIAL-ARTERY", Journal of the American College of Cardiology, 29(2), 1997, pp. 318-322

Abstract

Objectives. We sought to assess the prevalence of atherosclerotic lesions in the human brachial artery, Background, Many investigators haverecently studied endothelial and vascular function in the brachial circulation in humans to further their understanding of coronary artery disease and early atherogenesis. However, the prevalence of brachial atherosclerosis and its relation to coronary disease have never been documented, Methods. Arterial segments from the brachial, common carotidand left anterior descending coronary arteries were obtained during autopsy in 52 consecutively examined subjects (35 men, 17 women; 21 to 79 years old, mean [+/-SD] age 51 +/- 16) and studied by light microscopy using standard histologic techniques, Severity of the atherosclerotic lesions was categorized as fatty streaks (grade 1), fibrous plaques (grade 2) and advanced lesions (grade 3), Results. Atherosclerotic lesions of any grade were found in the brachial artery in 39 (75%) subjects, common carotid artery in 51 (98%) and left anterior descending coronary artery in 52 (100%), and the prevalence and severity of disease increased with age in all three arteries, The grade of lesion severity in the brachial and coronary arteries was significantly correlated (r = 0.41, p = 0.003), as was severity in the brachial and carotid arteries (r 0,53 p = 0.0001) and the carotid and coronary arteries (r = 0.69, p = 0.0001), The correlation between the brachial artery and the left anterior descending coronary artery aas highly significant in subjects less than or equal to 50 years old (r = 0.54, p = 0.002), but not in those greater than or equal to 50 years old (r = 0.37, p = NS), Conclusions, Atherosclerosis is common in the human brachial artery andis significantly correlated with both coronary and carotid disease, These results suggest that the brachial circulation may serve as a reasonable ''surrogate'' for studying atherosclerosis, particularly in younger adults. (C) 1997 by the American College of Cardiology.

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Documento generato il 05/04/20 alle ore 13:03:36