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Titolo:
PHYSICOCHEMICAL AND BIOLOGICAL STUDIES OF CORONA-TREATED ARTIFICIAL MEMBRANES USED FOR PANCREATIC-ISLETS ENCAPSULATION - MECHANISM OF DIFFUSION AND INTERFACE MODIFICATION
Autore:
KESSLER L; LEGEAY G; WEST R; BELCOURT A; PINGET M;
Indirizzi:
HOP UNIV,JEUNE EQUIPE MED,SERV ENDOCRINOL,PAVILLON LERICHE F-67091 STRASBOURG FRANCE UNIV STRASBOURG 1,JEUNE EQUIPE MED STRASBOURG FRANCE IRAP,DEPT MAT,CTTM LE MANS FRANCE CSMA LTD MANCHESTER LANCS ENGLAND
Titolo Testata:
Journal of biomedical materials research
fascicolo: 2, volume: 34, anno: 1997,
pagine: 235 - 245
SICI:
0021-9304(1997)34:2<235:PABSOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN ADSORPTION; BIOARTIFICIAL PANCREAS; POLYPROPYLENE FILM; DIABETIC RATS; BIOCOMPATIBILITY; TRANSPLANTATION; XENOGRAFTS; INVITRO; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
L. Kessler et al., "PHYSICOCHEMICAL AND BIOLOGICAL STUDIES OF CORONA-TREATED ARTIFICIAL MEMBRANES USED FOR PANCREATIC-ISLETS ENCAPSULATION - MECHANISM OF DIFFUSION AND INTERFACE MODIFICATION", Journal of biomedical materials research, 34(2), 1997, pp. 235-245

Abstract

The artificial AN69 membrane (Hospal), a synthetic copolymer composedof acrylonitrile and sodium methallyl sulphonate suitable for pancreatic islet encapsulation, was submitted to physicochemical treatment (Corona discharge) to improve its insulin permeability. X-ray photoelectron spectroscopy (XPS) analysis of the AN69 membrane indicated the presence of up to two molecular layers of glycerol at its surface while the surface energies revealed the presence of hydrophilic sites (-SO3Na/glycerol) located at the membrane surface and acrylonitrile hydrophobic groups inside the material. The Corona discharges decreased the number of glycerol molecules at the membrane surface and from a biological point of view, produced a threefold increase in insulin diffusion. Furthermore, the biocompatibility of the treated membrane was preservedafter 1 year of intraperitoneal implantation. The increase in insulinpermeability should result from a decrease of the membrane polarity and of a steric hindrance in pores. Thus, Corona discharge treatment may serve to optimize the properties of artificial membranes used for pancreatic islets encapsulation. (C) 1997 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:49:13