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Titolo:
PHOTOTHROMBOSIS USING 2 DIFFERENT PHTHALOCYANINE ADMINISTRATION ROUTES - CONTINUOUS IV INFUSION VERSUS BOLUS IV INJECTION
Autore:
TSILIMBARIS MK; PALLIKARIS IG; LYDATAKI S;
Indirizzi:
UNIV CRETE,SCH HLTH SCI,DIV MED,DEPT OPHTHALMOL,VARDINOYANNION EYE INST CRETE RETHIMNON GREECE UNIV CRETE,SCH HLTH SCI,DIV MED,DEPT OPHTHALMOL,VARDINOYANNION EYE INST CRETE RETHIMNON GREECE
Titolo Testata:
Photochemistry and photobiology
fascicolo: 3, volume: 62, anno: 1995,
pagine: 535 - 541
SICI:
0031-8655(1995)62:3<535:PU2DPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTODYNAMIC THERAPY; PHOTORADIATION THERAPY; VASCULAR OCCLUSION; TUMOR UPTAKE; HEMATOPORPHYRIN; THROMBOSIS; NEOVASCULARIZATION; PHARMACOKINETICS; PHOTOSENSITIZER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Tsilimbaris et al., "PHOTOTHROMBOSIS USING 2 DIFFERENT PHTHALOCYANINE ADMINISTRATION ROUTES - CONTINUOUS IV INFUSION VERSUS BOLUS IV INJECTION", Photochemistry and photobiology, 62(3), 1995, pp. 535-541

Abstract

Chloraluminum sulfonated phthalocyanine was administered in 22 albinorabbits either by means of bolus i.v. (intravenous) injection (6 mg/kg) or as continuous i.v. infusion. Eight animals were used for the comparison of plasma phthalocyanine change as a factor of time, using thetwo administration methods. Photothrombosis of corneal neovascularization was carried out in the remaining 14 animals either after bolus phthalocyanine injection or after continuous i.v. infusion. Irradiation of the right eye's vessels started 10 min after the injection in the bolus group and 35 min after initiation of infusion in the continuous infusion group. The vessels of each animal's left eye were irradiated 1h after the irradiation of the right eye, The initial peak of phthalocyanine concentration after bolus injection was followed by a rapid decrease of plasma levels. In the continuous infusion group, 30-40 min after the initiation of infusion, plasma phthalocyanine concentration reached a plateau that remained stable for the rest of the 80-90 min ofinfusion. Using bolus injection, a significant decrease of phthalocyanine concentration was accompanied by a significant increase of irradiation time necessary for neovascularization thrombosis in the two eyes. Irradiation time as well as phthalocyanine concentration did not differ between the two eyes using continuous infusion. Vascular photosensitivity seemed to be higher using continuous i.v. infusion of phthalocyanine. Continuous i.v. infusion represents an interesting alternativeto bolus injection for phthalocyanine-mediated corneal neovascularization photothrombosis.

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Documento generato il 25/01/21 alle ore 15:17:41