Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CARDIORESPIRATORY RESPONSES TO ACUTE-HYPOXIA AND HYPEROXIA IN ADULT AND NEONATAL SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
Autore:
GRISK O; EXNER J; SCHMIDT M; WACKER S; WERNER M; HONIG A;
Indirizzi:
UNIV GREIFSWALD,FAC MED,DEPT PHYSIOL,RUBENOWSTR 3 D-17487 GREIFSWALD GERMANY
Titolo Testata:
Clinical and experimental hypertension
fascicolo: 7, volume: 17, anno: 1995,
pagine: 1025 - 1047
SICI:
1064-1963(1995)17:7<1025:CRTAAH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED RAT; SYSTEMIC HYPOXIA; DENERVATED RATS; HYPERCAPNIA; INHIBITION;
Keywords:
HYPERTENSION; RATS; NEONATAL RATS; CHEMOREFLEX; VENTILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
O. Grisk et al., "CARDIORESPIRATORY RESPONSES TO ACUTE-HYPOXIA AND HYPEROXIA IN ADULT AND NEONATAL SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS", Clinical and experimental hypertension, 17(7), 1995, pp. 1025-1047

Abstract

The aim of this study was to investigate whether there are differences between particular characteristics of breathing regulation in primary hypertensive and normotensive states which might indicate significant differences in arterial chemoreceptor reflex function. Under air-breathing conditions, minute ventilation was similar in adult spontaneously hypertensive rats (SHR) (50 +/- 2 ml/min x 100 g) and in Wistar-Kyoto rats (WKY) (54 +/- 3 ml/min x 100 g) but significantly lower in randomly bred normotensive Wistar rats (NWR) (39 +/- 1 ml/min x 100 g). In seven-day-old rats minute ventilation was 10.5 +/- 1.2 ml/min x 10 gin SHR and 10.2 +/- 1.4 ml/min x 10 g in WKY. Our data indicate that there is no elevation of the ventilatory drive under air-breathing conditions which can be unequivocally associated with primary hypertension in adult and neonatal animals. Acute inhibition of ventilation caused by hyperoxia indicated that oxygen dependent peripheral chemoreceptor activity during air-breathing was similar in SHR and normotensive controls both in the unanesthetized neonatal state and in anesthetized adult animals. No well defined association between the characteristics of the hypoxic ventilatory response and primary hypertension could be demonstrated although responses in adult anesthetized SHR tended to befaster and of higher amplitude than in normotensive controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:26:03