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Titolo:
EXPRESSION OF C-ERB B-2 PROTEIN AND DNA-PLOIDY IN BREAST CARCINOGENESIS
Autore:
SCHMITT FC; FIGUEIREDO P; LACERDA M;
Indirizzi:
PORTO MED SCH,IPATIMUP,DEPT PATHOL P-4200 OPORTO PORTUGAL UNIV ESTADUAL PAULISTA,SCH MED,DEPT PATHOL SAO PAULO BRAZIL UNIV OPORTO,INST PATOL & IMMUNOL MOLEC,MOLEC PATHOL UNIT P-4100 OPORTO PORTUGAL INST CANC RES,DEPT PATHOL COIMBRA PORTUGAL
Titolo Testata:
Archives of pathology and laboratory medicine
fascicolo: 9, volume: 119, anno: 1995,
pagine: 815 - 820
SICI:
0003-9985(1995)119:9<815:EOCBPA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCTAL CARCINOMA INSITU; HER-2 NEU ONCOGENE; C-ERBB-2 ONCOGENE; IMMUNOHISTOCHEMICAL EVALUATION; INTRADUCTAL CARCINOMAS; PROGNOSTIC FACTORS; CANCER; HYPERPLASIA; DISEASE; BENIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
F.C. Schmitt et al., "EXPRESSION OF C-ERB B-2 PROTEIN AND DNA-PLOIDY IN BREAST CARCINOGENESIS", Archives of pathology and laboratory medicine, 119(9), 1995, pp. 815-820

Abstract

Objective.-to examine the c-erb B-2 expression and nuclear DNA content in samples of breast lesions to ascertain any relationship between c-erb B-2 expression and aneuploidy in the different types of proliferative breast lesions and in intraductal and invasive carcinomas. Designand Setting.-lmmunohistochemical analysis of c-erb B-2 expression andcytometric nuclear DNA assessment were performed in a series of 39 cases of intraductal hyperplasia without atypia, 7 cases of intraductal hyperplasia with atypia, 64 cases of intraductal carcinoma, and 85 cases of invasive breast carcinoma (30 of which had extensive intraductalcomponent). Results.-Overexpression of c-erb B-2 was seen only in cases of carcinoma: 28 (43.7%) intraductal carcinomas and 15 (17.6%) invasive carcinomas. Aneuploidy was demonstrated in 3 (43.0%) cases of intraductal hyperplasia with atypia, in 54 (84.4%) cases of intraductal carcinoma, and in 63 (74.2%) cases of invasive carcinoma. All cases of intraductal hyperplasia without atypia were euploid and none expressedc-erb B-2. Among the carcinomas (intraductal and invasive) there was a strong relationship between aneuploidy and c-erb B-2 expression. In most instances, the intraductal and invasive components of the 30 invasive carcinomas with extensive intraductal component displayed similarDNA content and c-erb B-2 immunoreactivity; whenever there was a difference, the intraductal component tended to be aneuploid (five out of six cases) and c-erb B-2 positive (one case), in contrast to the respective invasive component. Conclusions.-The higher frequency of aneuploidy and c-erb B-2 expression in intraductal carcinomas in comparison with invasive carcinomas suggests there is not a linear relationship between DNA content abnormalities and neoplastic progression and that some invasive breast carcinomas evolve without an identifiable intraductal phase or are unrelated to disturbances at the c-erb B-2 locus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:56:10