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Titolo:
E-CADHERIN EXPRESSION IN PAPILLARY TRANSITIONAL-CELL CARCINOMA OF THEURINARY-BLADDER
Autore:
ROSS JS; DELROSARIO AD; FIGGE HL; SHEEHAN C; FISHER HAG; BUI HX;
Indirizzi:
ALBANY MED COLL,DEPT PATHOL & LAB MED,47 NEW SCOTLAND AVE ALBANY NY 12208 ALBANY MED COLL,DEPT UROL SURG ALBANY NY 12208 SAMUEL S STRATTON VET ADM MED CTR,DEPT PATHOL ALBANY NY 00000
Titolo Testata:
Human pathology
fascicolo: 9, volume: 26, anno: 1995,
pagine: 940 - 944
SICI:
0046-8177(1995)26:9<940:EEIPTC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; ADHESION MOLECULES; DECREASED EXPRESSION; TUMOR PROGRESSION; PROSTATE-CANCER; GASTRIC-CANCER; DNA PLOIDY; METASTASIS; TISSUES; GRADE;
Keywords:
TRANSITIONAL CELL CARCINOMA; CELL ADHESION MOLECULE; E-CADHERIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Ross et al., "E-CADHERIN EXPRESSION IN PAPILLARY TRANSITIONAL-CELL CARCINOMA OF THEURINARY-BLADDER", Human pathology, 26(9), 1995, pp. 940-944

Abstract

E-cadherin (ECD), a cell adhesion molecule that plays a diverse role in cell-cell and cell-matrix interaction, has recently been associatedwith tumor invasion and metastasis. We evaluated the ECD expression in 55 cases of urinary bladder papillary transitional cell carcinoma using a double-linked immunoalkaline phosphatase procedure on formalin-fixed, paraffin-embedded specimens quantified as percentage positive staining area with the Roche RPW image analyzer (Roche Image Analysis Systems, Elon College, NC). The 10 grade I tumors stained intensely for ECD (66%) and showed enhanced staining compared with normal transitional epithelium. The 20 grade II lesions stained moderately at 45%, and the 25 grade III lesions showed weak expression of ECD with a 33% positive stain. This loss of expression for high-grade versus low-grade tumors was statistically significant (P<.02). There was a similar decrease in E-CD expression for high-stage versus low-stage specimens with 30 stage 0 and stage A cases having an average of 51% positive stain and 25 stage B, C, and D cases having an average stain of 33%. This difference was also statistically significant (P<.001). We conclude that loss of expression of ECD in high-grade, high-stage urinary bladder transitional cell carcinoma is associated with significant bladder wall invasion, indicates potential for metastasis, and may be of clinical value in the assessment of prognosis and planning of therapy for patients with bladder tumors. Copyright (C) 1995 by W.B. Saunders Company

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Documento generato il 15/07/20 alle ore 08:43:11