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Titolo:
NEUROBIOLOGY OF OCULAR PAIN
Autore:
BELMONTE C; GARCIAHIRSCHFELD J; GALLAR J;
Indirizzi:
UNIV ALICANTE,INST NEUROCIENCIAS,APTDO 374 E-03080 ALICANTE SPAIN UNIV ALICANTE,DEPT FISIOL E-03080 ALICANTE SPAIN
Titolo Testata:
Progress in retinal and eye research
fascicolo: 1, volume: 16, anno: 1997,
pagine: 117 - 156
SICI:
1350-9462(1997)16:1<117:NOOP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; IMMUNOREACTIVE NERVE-FIBERS; TRIGEMINAL NOCICEPTIVE NEURONS; FOS-LIKE IMMUNOREACTIVITY; SUBNUCLEUS RETICULARIS-VENTRALIS; SUBSTANCE-P IMMUNOREACTIVITY; NOXIOUS THERMAL-STIMULATION; RABBIT CORNEAL EPITHELIUM; ANTERIOR EYE SEGMENT; SENSORY NERVES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
291
Recensione:
Indirizzi per estratti:
Citazione:
C. Belmonte et al., "NEUROBIOLOGY OF OCULAR PAIN", Progress in retinal and eye research, 16(1), 1997, pp. 117-156

Abstract

Ocular irritation and pain are associated with many clinical situations (e.g. accidental injury, eye diseases, surgery and contact lens wearing). Pain and related ocular sensations begin with stimulation by injurious stimuli of first-order sensory neurons uf the trigeminal ganglion. Neurons responding solely to application in their receptive fieldof noxious mechanical forces (mechanonociceptive neurons), or of irritant chemicals and heat (polymodal nociceptive neurons), have been identified electrophysiologically in the conjunctiva, cornea, sclera, iris, ciliary body and choroid. The cornea is additionally innervated by neurons responding to low temperatures, which may account for corneal discomfort caused by cold. Also, low-threshold mechanoreceptive and cold-sensitive neurons supply the conjunctiva and sclera, possibly mediating touch and thermal sensations aroused by innocuous stimuli in the front of the eye. Ocular sensory information is transmitted from the trigeminal ganglion to specific higher-order neurons located in the trigeminal brainstem nuclear complex, the thalamus and the cerebral fortes. Local ocular inflammatory responses enhance injury-induced neural activity both in ocular nociceptive terminals and in higher order neurons. In addition to signalling acute lesions, ocular primary sensory neurons participate in post-injury processes, contributing to local inflammatory reactions (neurogenic inflammation) and io the repair of damaged tissues. These effects are mediated at least in part, by substanceP and CGRP, two neuropeptides contained in ocular sensory nerves cells that are released peripherally upon tissue damage. Ocular tissues have a trophic interdependence with their sensory neurons. Ocular tissues are the source of neurotrophic factors that are critical for the early development and survival of trigeminal sensory neurons. On the other hand, the morphofunctional integrity of some ocular tissues like thecontra. appears to be dependent on the presence of an intact sensory innervation, Stimulation of ocular sensory pathways by noxious mechanical, chemical and thermal stimulation of cornea, conjunctiva or of other eye structures, evokes distinct types of ocular sensations. Differences in the quality of pain sensation presumably result from the magnitudes of activation of the various sub-populations of ocular nociceptive neurons by different stimulus modalities. In addition to conscious sensations, injurious stimuli evoke protective reflexes (blinking and lacrimation) aimed at protecting the rye and minimizing further oculardamage by noxious stimuli. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:54:07