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Titolo:
INVOLVEMENT OF PERIPHERAL PRESYNAPTIC INHIBITION IN THE REDUCTION OF SYMPATHETIC TONE BY MOXONIDINE, RILMENIDINE AND UK-14304
Autore:
URBAN R; SZABO B; STARKE K;
Indirizzi:
UNIV FREIBURG,INST PHARMAKOL,HERMANN HERDER STR 5 D-79104 FREIBURG GERMANY UNIV FREIBURG,INST PHARMAKOL D-79104 FREIBURG GERMANY
Titolo Testata:
European journal of pharmacology
fascicolo: 1-3, volume: 282, anno: 1995,
pagine: 29 - 37
SICI:
0014-2999(1995)282:1-3<29:IOPPII>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT PULMONARY-ARTERY; ALPHA-ADRENOCEPTOR AGONISTS; NORADRENALINE RELEASE; IMIDAZOLINE RECEPTORS; NERVE ACTIVITY; BRAIN CORTEX; CLONIDINE; RAT; ALPHA-2-ADRENOCEPTORS; MODULATION;
Keywords:
ALPHA(2)-ADRENOCEPTOR; IMIDAZOLINE RECEPTOR; PRESYNAPTIC INHIBITION; MOXONIDINE; RILMENIDINE; UK 14304;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
R. Urban et al., "INVOLVEMENT OF PERIPHERAL PRESYNAPTIC INHIBITION IN THE REDUCTION OF SYMPATHETIC TONE BY MOXONIDINE, RILMENIDINE AND UK-14304", European journal of pharmacology, 282(1-3), 1995, pp. 29-37

Abstract

We studied the possibility that presynaptic inhibition of transmitterrelease from postganglionic sympathetic neurons contributes to the overall reduction of sympathetic tone produced by moxonidine, rilmenidine and 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline tartrate (UK 14304). In pithed rabbits without electric stimulation, moxonidine, rilmenidine and UK 14304 caused a long-lasting, > 10 min, increase in arterial pressure. Heart rate was not changed. In pithed rabbits in which sympathetic tone was created by electric stimulation through the pithingrod (2 Hz), the same doses of moxonidine, rilmenidine and UK 14304 caused only a brief, < 10 min, blood pressure rise. Heart rate was decreased, as were the plasma concentrations of noradrenaline and adrenaline. Dose-response curves for the effects on the plasma noradrenaline concentration (stimulated pithed rabbits) were compared with previously obtained dose-response curves for depression of renal sympathetic nerve activity (conscious rabbits). For each drug, the curve describing peripheral presynaptic inhibition and the curve describing central sympathoinhibition were very similar. Both the power and the dose dependence of the peripheral inhibitory effect support its contribution to the overall decrease in sympathetic tone produced by clonidine-like drugs in intact animals. The peripheral effect in all likelihood consists inactivation of presynaptic alpha(2)-autoreceptors. The agreement of the dose-response curves for the peripheral and for the central effect supports the view that the central effect, like the peripheral one, is mediated through alpha(2)-adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 14:22:20