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Titolo:
LONG-TERM TOLERABILITY AND EFFICACY OF CABERGOLINE, A NEW LONG-ACTINGDOPAMINE AGONIST, IN PARKINSONS-DISEASE
Autore:
INZELBERG R; NISIPEANU P; RABEY MJ; KORCZYN AD;
Indirizzi:
TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Movement disorders
fascicolo: 5, volume: 10, anno: 1995,
pagine: 604 - 607
SICI:
0885-3185(1995)10:5<604:LTAEOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Keywords:
PARKINSONS DISEASE; MOTOR FLUCTUATIONS; ON-OFF PHENOMENON; DYSKINESIAS; CABERGOLINE; DOPAMINE AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R. Inzelberg et al., "LONG-TERM TOLERABILITY AND EFFICACY OF CABERGOLINE, A NEW LONG-ACTINGDOPAMINE AGONIST, IN PARKINSONS-DISEASE", Movement disorders, 10(5), 1995, pp. 604-607

Abstract

Motor fluctuations constitute a severe complication of chronic levodopa therapy. The addition of dopamine agonists may partially alleviate these responses; however, due to the short half-life of these drugs, several daily doses are required. Cabergoline is a new dopamine agonistwith a long half-life and can be given in a single daily dose. Seventeen patients with severe fluctuations were treated with cabergoline, seven of them for >1 year (up to 39 months). The motor status ameliorated and the percentage of ''off'' hours significantly decreased in the first year and did not increase significantly later during long-term follow-up. Cabergoline is a promising treatment for parkinsonian patients with motor fluctuations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:02:09