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Titolo:
ACCUMULATION OF CYCLIC ADP-RIBOSE MEASURED BY A SPECIFIC RADIOIMMUNOASSAY IN DIFFERENTIATED HUMAN LEUKEMIC HL-60 CELLS WITH ALL-TRANS-RETINOIC ACID
Autore:
TAKAHASHI K; KUKIMOTO I; TOKITA KI; INAGEDA K; INOUE SI; KONTANI K; HOSHINO SI; NISHINA H; KANAHO Y; KATADA T;
Indirizzi:
UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHYSIOL CHEM TOKYO 113 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHYSIOL CHEM TOKYO 113 JAPAN TOKYO INST TECHNOL,DEPT LIFE SCI YOKOHAMA KANAGAWA 227 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 371, anno: 1995,
pagine: 204 - 208
SICI:
0014-5793(1995)371:2<204:AOCAMB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE ANTIGEN CD38; EGG-SPECIFIC NADASE; 2ND-MESSENGER ENZYME; HUMAN ERYTHROCYTES; OUTER SURFACE; HYDROLYSIS; MOLECULE; ACTIVATION; RELEASE; CYCLASE;
Keywords:
ADP-RIBOSYL CYCLASE; CD38 ANTIGEN; CYCLIC ADP-RIBOSE; NAD(+) GLYCOHYDROLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Takahashi et al., "ACCUMULATION OF CYCLIC ADP-RIBOSE MEASURED BY A SPECIFIC RADIOIMMUNOASSAY IN DIFFERENTIATED HUMAN LEUKEMIC HL-60 CELLS WITH ALL-TRANS-RETINOIC ACID", FEBS letters, 371(2), 1995, pp. 204-208

Abstract

Cyclic adenosine diphosphoribose (cADPR) is a novel candidate for themediator of Ca2+ release from intracellular Ca2+ stores, The formation of this cyclic nucleotide is catalyzed by not only Aplysia ADP-ribosyl cyclase but also an ecto-form enzyme of NAD(+) glycohydrolase (NADase), which was previously identified as all-trans-retinoic acid (RA)-inducible CD38 in human leukemic HL-60 cells, In the present study, we developed a radioimmunoassay specific for cADPR, by which more than 100 fmol of cADPR could be detected without any interference by other nucleotides. The possible involvement of CD38 in, the formation of cellular cADPR was investigated with the radioimmunoassay method, A marked increase in cellular cADPR was accompanied by all-trans-RA-induced differentiation of HL-60 cells, Moreover, a high level of cellular cADPR was observed in other leukemic cell lines, in which CD38 mRNA was expressed, Thus, CD38, which was initially identified as an NADase, appeared to be responsible for the formation of cellular cADPR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:08:50