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Titolo:
CALCITONIN-GENE-RELATED PEPTIDE-IMMUNOREACTIVE AND SUBSTANCE-P-IMMUNOREACTIVE AXONS IN THE NUCLEUS GRACILIS OF THE RAT WITH SPECIAL REFERENCE TO AXONAL DYSTROPHY - LIGHT AND ELECTRON-MICROSCOPIC OBSERVATIONS
Autore:
FUJIWARA K; BAEK SY; ARAKAWA T; KOBAYASHI K; TAKAGI H;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU,1-4-54 ASAHI MACHI OSAKA545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT INTERNAL MED 3 OSAKA 545 JAPAN PUSAN NATL UNIV,COLL MED,DEPT ANAT PUSAN 609735 SOUTH KOREA
Titolo Testata:
Acta Neuropathologica
fascicolo: 4, volume: 90, anno: 1995,
pagine: 347 - 355
SICI:
0001-6322(1995)90:4<347:CPAS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROAXONAL DYSTROPHY; SENSORY NEURONS; CO-EXISTENCE; FIBERS; COEXISTENCE; COLUMN;
Keywords:
NUCLEUS GRACILIS; AXONAL DYSTROPHY; CALCITONIN GENE-RELATED PEPTIDE; SUBSTANCE P; IMMUNOELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Fujiwara et al., "CALCITONIN-GENE-RELATED PEPTIDE-IMMUNOREACTIVE AND SUBSTANCE-P-IMMUNOREACTIVE AXONS IN THE NUCLEUS GRACILIS OF THE RAT WITH SPECIAL REFERENCE TO AXONAL DYSTROPHY - LIGHT AND ELECTRON-MICROSCOPIC OBSERVATIONS", Acta Neuropathologica, 90(4), 1995, pp. 347-355

Abstract

Calcitonin gene-related peptide (CGRP) and substance P (SP)-immunoreactive (IR) axons in the nucleus gracilis of normal rats (1-15 months of age) were studied by light and electron microscopy. Besides many CGRP-LR and SP-IR varicosities with normal appearance, we found a few swollen (nearly round or oval) varicosities with either CGRP or SP immunoreactivity. Swollen CGRP-IR varicosities were more frequently seen than SP-IR ones, appearing from 3 months of age and increasing in number and size (up to approximately 25 mu m in diameter) with advancing age. At the electron microscopic (EM) level, CGRP-LR and SP-LR swollen varicosities showed dystrophic changes, i.e., many membranous dense bodies, and proliferation of microtubules and neurofilaments. CGRP-IR or SP-IR dystrophic axons also contained many mitochondria and sometimes made synaptic contacts with nonreactive dendrites (occasionally with non-IR axons). These findings suggest that the dystrophic CGRP and SP axonal profiles represent a functionally distinct subpopulation of axonaldystrophy in the nucleus gracilis and use CGRP or SP as a neuroactivesubstance. Using a double-immunostaining method, many of normal CGRP-IR axons were identified to be SP-IR. However, no single dystrophic varicosity was found to contain both CGRP and SP immunoreactivities. These findings suggest that CGRP and SP afferents are independently affected and progress to dystrophic changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:04:21