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Titolo:
ACTIVITY OF PLATINUM DRUGS AGAINST MELANOMA CELL-LINES - IS IT MODULATED IN-VITRO IN THE PRESENCE OF TAMOXIFEN
Autore:
MOHAMMED MQ; PHOTIOU A; SHAH P; RETSAS S;
Indirizzi:
CHARING CROSS HOSP,DEPT MED ONCOL,CATHERINE GRIFFITHS CANC RES LAB,MELANOMA UNIT LONDON W6 8RF ENGLAND CHARING CROSS HOSP,DEPT MED ONCOL,CATHERINE GRIFFITHS CANC RES LAB,MELANOMA UNIT LONDON W6 8RF ENGLAND
Titolo Testata:
Anticancer research
fascicolo: 4, volume: 15, anno: 1995,
pagine: 1319 - 1326
SICI:
0250-7005(1995)15:4<1319:AOPDAM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; METASTATIC MELANOMA; CYTO-TOXICITY; CISPLATIN; DNA; CIS-DIAMMINEDICHLOROPLATINUM(II); PHARMACOKINETICS; GLYCOPROTEIN;
Keywords:
MELANOMA; TAMOXIFEN; CISPLATIN; CARBOPLATIN; MEDIAN EFFECT ANALYSIS; CHEMOPOTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.Q. Mohammed et al., "ACTIVITY OF PLATINUM DRUGS AGAINST MELANOMA CELL-LINES - IS IT MODULATED IN-VITRO IN THE PRESENCE OF TAMOXIFEN", Anticancer research, 15(4), 1995, pp. 1319-1326

Abstract

Cisplatin and carboplatin have been used against human malignant melanoma as single agents and in combination. Tamoxifen;is used in the treatment of breast cancer; but has no significant activity against humanmalignant melanoma. Tamoxifen, however; has been promoted as a modulator in some drug regimens. The addition of tamoxifen to cisplatin or carboplatin has been reported to enhance their activity against the human melanoma cell line T-289. We investigated whether tamoxifen potentiates, in vitro, the activity of cisplatin and carboplatin against C32,G361 and StMl11a melanoma cell fines. Tamoxifen alone at clinically achievable concentrations of 0.1 and 1.0 mu M (168 ha exposure) had no significant effect on growth. No chemopotentiation of the activity of cisplatin ol carboplatin was observed with the addition of tamoxifen (0.1 and 1.0 mu M). The platinum drugs were added for I hr (serially diluted from 100.0 mu M). Against the G361 line there was a trend towards chemopotentiation of cisplatin by 0.1 mu M of tamoxifen. However; this did not reach stastistical significance. Tamoxifen (5.0 and 10.0 muM) produced some inhibitory activity and a trend towards synergy withcisplatin was observed. However, these concentrations are not clinically feasible. Previous reports detecting synergistic interaction between tamoxifen (0.1 and LO mu M), and the platinum compounds against theT-289 melanoma cell line cannot be supported in our in vitro system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:02:21