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Titolo:
STRIATAL DOPAMINE-2 RECEPTOR OCCUPANCY IN PSYCHOTIC-PATIENTS TREATED WITH RISPERIDONE
Autore:
KUFFERLE B; BRUCKE T; TOPITZSCHRATZBERGER A; TAUSCHER J; GOSSLER R; VESELY C; ASENBAUM S; PODREKA I; KASPER S;
Indirizzi:
UNIV VIENNA,HOSP PSYCHIAT,DEPT GEN PSYCHIAT,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,HOSP NEUROL,DEPT GEN NEUROL VIENNA AUSTRIA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 68, anno: 1996,
pagine: 23 - 30
SICI:
0925-4927(1996)68:1<23:SDROIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL NEUROLEPTICS; IN-VIVO; SCHIZOPHRENIA; BLOCKADE; SCALE;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; HALOPERIDOL; BASAL GANGLIA; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B. Kufferle et al., "STRIATAL DOPAMINE-2 RECEPTOR OCCUPANCY IN PSYCHOTIC-PATIENTS TREATED WITH RISPERIDONE", PSYCHIATRY RESEARCH-NEUROIMAGING, 68(1), 1996, pp. 23-30

Abstract

Seventeen psychiatric patients (11 with schizophrenia, 5 with other psychotic disorders, and 1 with obsessive-compulsive disorder) were examined by single photon emission computed tomography with I-123-iodobenzamide (IBZM) as tracer. Patients were treated with risperidone in twodifferent dosage groups (3 mg and 8 mg) and haloperidol (10-20 mg) and compared with eight healthy control subjects. There was a statistically significant difference in basal ganglia/frontal cortex ratios of IBZM binding between controls and all treatment groups. A statisticallysignificant difference was also found concerning these ratios and percentage of dopamine D-2 receptor occupancy rates between the treatmentgroups with lowest ratios and highest percentage of D-2 receptor occupancy in the group of patients treated with haloperidol, followed by the group treated with 8 mg of risperidone and the group treated with 3mg of risperidone. Copyright (C) 1996 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:49:31