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Titolo:
GENETIC-VARIATION OF WILD PUUMALA VIRUSES WITHIN THE SEROTYPE, LOCAL RODENT POPULATIONS AND INDIVIDUAL ANIMAL
Autore:
PLYUSNIN A; VAPALAHTI O; LEHVASLAIHO H; APEKINA N; MIKHAILOVA T; GAVRILOVSKAYA I; LAAKKONEN J; NIEMIMAA J; HENTTONEN H; BRUMMERKORVENKONTIO M; VAHERI A;
Indirizzi:
HELSINKI UNIV,HAARTMAN INST,DEPT VIROL,POB 21 SF-00014 HELSINKI FINLAND RES INST POLIOMYELITIS & VIRAL ENCEPHALITIS MOSCOW RUSSIA COLL VET MED,DEPT ANAT SF-00581 HELSINKI FINLAND FINNISH FOREST RES INST,DEPT FOREST ECOL SF-01301 VANTAA FINLAND
Titolo Testata:
Virus research
fascicolo: 1, volume: 38, anno: 1995,
pagine: 25 - 41
SICI:
0168-1702(1995)38:1<25:GOWPVW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-SEQUENCE ANALYSIS; VOLE MONOCLONAL-ANTIBODIES; S-GENOME SEGMENTS; STRAIN HALLNAS B1; NEPHROPATHIA-EPIDEMICA; HEMORRHAGIC-FEVER; RENAL SYNDROME; MOLECULAR CHARACTERIZATION; HANTAAN VIRUS; BANK VOLES;
Keywords:
EVOLUTION; GENETIC VARIATION; HANTAVIRUS; PUUMALA VIRUS; QUASI-SPECIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
A. Plyusnin et al., "GENETIC-VARIATION OF WILD PUUMALA VIRUSES WITHIN THE SEROTYPE, LOCAL RODENT POPULATIONS AND INDIVIDUAL ANIMAL", Virus research, 38(1), 1995, pp. 25-41

Abstract

Reverse transcriptase polymerase chain reaction cloning and sequencing were used to determine the range of S gene/N protein variability in wild Puumala virus (PUU) strains and to study phylogenetic relationships between two groups of strains which originated from Finland and from European Russia. Analyses of the nucleotide and predicted amino acidsequences showed: (1) all PUU strains shared a common ancient ancestor; and (2) the more recent ancestors were different for the Finnish branch and the Russian branch of PUU strains. A cluster of amino acid substitutions in the N protein of Finnish strains was found; this cluster was located within a highly variable region of the molecule carryingB-cell epitopes (Vapalahti et al., J. Med. Virol., 1995, in press). Different levels of S gene/N protein diversity of PUU were revealed supporting the view of geographical clustering of genetic variants. Puumala virus from individual voles was found to be a complex mixture of closely related variants-quasispecies. The ratio of non-silent to silentnucleotide mutations registered in the S genes/N proteins of PUU quasispecies was 4- to 16-fold higher than that in Puumala virus strains, resulting in a more wide range of quasispecies N protein sequence diversity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:43:23