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Titolo:
VOLATILE AND INTRAVENOUS ANESTHETICS SELECTIVELY ATTENUATE THE RELEASE OF ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR ELICITED BY BRADYKINININ THE CORONARY MICROCIRCULATION
Autore:
LISCHKE V; BUSSE R; HECKER M;
Indirizzi:
UNIV FRANKFURT KLINIKUM,ZENTRUM PHYSIOL,THEODOR STERN KAI 7 D-60590 FRANKFURT GERMANY UNIV FRANKFURT KLINIKUM,ZENTRUM PHYSIOL D-60590 FRANKFURT GERMANY UNIV FRANKFURT KLINIKUM,ZENTRUM ANASTHESIE & WIEDERBELEBUNG D-60590 FRANKFURT GERMANY
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 352, anno: 1995,
pagine: 346 - 349
SICI:
0028-1298(1995)352:3<346:VAIASA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID; ARTERIES; RELAXATION;
Keywords:
BRADYKININ; ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR; VASODILATATION; CORONARY MICROCIRCULATION; ANESTHETICS; CYTOCHROME P450;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
V. Lischke et al., "VOLATILE AND INTRAVENOUS ANESTHETICS SELECTIVELY ATTENUATE THE RELEASE OF ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR ELICITED BY BRADYKINININ THE CORONARY MICROCIRCULATION", Naunyn-Schmiedeberg's archives of pharmacology, 352(3), 1995, pp. 346-349

Abstract

In addition to nitric oxide (NO) and prostacyclin (PGI,) another endothelium-derived factor, which hyperpolarizes vascular smooth muscle cell via activation of Kt channels, contributes to the vasorelaxant effect of bradykinin in different vascular beds. Preliminary findings suggest that this endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation is attenuated by both volatile and intravenous anesthetics. Since EDHF may play an important role in the coronary microcirculation, we investigated the effects of isoflurane (2 vol.% equivalent to similar to 250 mu M), etomidate (30 and 100 mu M), phenobarbital (100 mu M) and thiopental (30 and 100 mu M) on the EDHF-mediated dilator response to bradykinin and on the endothelium-independent dilatation evoked by sodium nitroprusside (SNP) in the isolated saline-perfusedrat heart (Langendorff preparation). None of the anesthetics tested affected the dilator response to bradykinin or SNP under basal conditions. However, following inhibition of NO and PGI(2) formation with N-G-nitro-L-arginine (100 mu M) and diclofenac (1 mu M) respectively, isoflurane, etomidate and thiopental, but not phenobarbital, significantlyattenuated the NO/PGI(2)-independent, i.e. EDHF-mediated dilator response to bradykinin, while the vasorelaxant effect of SNP remained unaffected. Isoflurane, etomidate and thiopental, but not phenobarbital, display cytochrome P450-inhibiting properties, suggesting that these anesthetics impair the cytochrome P450-dependent synthesis of EDHF in the coronary microcirculation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 10:03:15