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Titolo:
HIGH-CONCENTRATIONS OF ATRIAL-NATRIURETIC-PEPTIDE AND BRAIN NATRIURETIC PEPTIDE IN RAT PERICARDIAL FLUID AND THEIR REDUCTION BY RESERPINE IN-VIVO
Autore:
KLEMOLA R; LAINE M; WECKSTROM M; VUOLTEENAHO O; RUSKOAHO H; HUTTUNEN P; LEPPALUOTO J;
Indirizzi:
UNIV OULU,DEPT PHYSIOL,KAJAANINTIE 52A SF-90220 OULU FINLAND UNIV OULU,DEPT PHYSIOL SF-90220 OULU FINLAND UNIV OULU,DEPT PHARMACOL & TOXICOL SF-90220 OULU FINLAND UNIV OULU,DEPT FORENS MED SF-90220 OULU FINLAND
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 352, anno: 1995,
pagine: 331 - 336
SICI:
0028-1298(1995)352:3<331:HOAABN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELEASE; MYOCARDIUM; VOLUME; TISSUE; CELLS;
Keywords:
ANP; BNP; RAT HEART; PERICARDIAL FLUID; PLASMA; RESERPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Klemola et al., "HIGH-CONCENTRATIONS OF ATRIAL-NATRIURETIC-PEPTIDE AND BRAIN NATRIURETIC PEPTIDE IN RAT PERICARDIAL FLUID AND THEIR REDUCTION BY RESERPINE IN-VIVO", Naunyn-Schmiedeberg's archives of pharmacology, 352(3), 1995, pp. 331-336

Abstract

We determined concentrations and molecular sizes of natriuretic peptides in rat pericardial fluid and plasma by use of specific radioimmunoassays (RIA) and gel filtration HPLC. Our study shows that pericardialfluid forms a local extracellular storage of immunoreactive (ir) atrial natriuretic peptide (irANP) and brain natriuretic peptide (irBNP) near the heart where these peptides can be found in high concentrationsin vivo. The concentrations of irANP, irBNP and NH2-terminal fragmentof proANP (irNT-proANP) in pericardial fluid were 9.8 +/- 3.7, 0.49 +/- 0.47 and 28.9 +/- 11.8 nmol/l, respectively. IrBNP had the lowest (20 +/- 11) and irANP the highest (90 +/- 32) concentration ratio between pericardial fluid and plasma. The elution positions of irANP, irBNPand irNT-proANP in pericardial fluid and plasma were similar as examined by gel filtration HPLC. Furthermore, we show that the reduction ofnoradrenaline content of the heart muscle by reserpine reduces concentration of irANP in pericardial fluid by 39.6% and in plasma by 30.3% when compared to respective control group values. The concentration ofirBNP is reduced by 44.1% in pericardial fluid but in plasma its reduction was not statistically significant. Vasoactive peptides released into the interstitial space and from there into pericardial fluid may have a more active role in the regulation of cardiac function than previously considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:45:31