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Titolo:
INHIBITION BY CARBAMAZEPINE OF VARIOUS ION CHANNELS MEDIATED CATECHOLAMINE SECRETION IN CULTURED BOVINE ADRENAL-MEDULLARY CELLS
Autore:
YOSHIMURA R; YANAGIHARA N; TERAO T; MINAMI K; ABE K; IZUMI F;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHARMACOL,YAHATANISHI KU,1-1 ISEIGAOKA,KITAKYUSHU 807 FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHARMACOL,YAHATANISHI KU FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PSYCHIAT,YAHATANISHI KU FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT ANESTHESIOL,YAHATANISHI KU FUKUOKA JAPAN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 352, anno: 1995,
pagine: 297 - 303
SICI:
0028-1298(1995)352:3<297:IBCOVI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMAFFIN CELLS; ACETYLCHOLINE-RECEPTOR; CALCIUM CHANNELS; NA-22 INFLUX; BINDING; DRUGS; CURRENTS; NEURONS; LITHIUM;
Keywords:
ADRENAL MEDULLARY CELLS; CARBAMAZEPINE; NICOTINIC ACETYLCHOLINE RECEPTOR-ASSOCIATED ION CHANNEL; VOLTAGE-DEPENDENT NA+ CHANNEL; VOLTAGE-DEPENDENT CA2+ CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R. Yoshimura et al., "INHIBITION BY CARBAMAZEPINE OF VARIOUS ION CHANNELS MEDIATED CATECHOLAMINE SECRETION IN CULTURED BOVINE ADRENAL-MEDULLARY CELLS", Naunyn-Schmiedeberg's archives of pharmacology, 352(3), 1995, pp. 297-303

Abstract

The effects of carbamazepine (CBZ) on Na-22(+) influx, Ca-45(2+) influx, catecholamine secretion and cyclic GMP production were examined incultured bovine adrenal medullary cells. 1) CBZ (40-120 mu mol/l) inhibited Na-22(+) influx evoked by carbachol in a concentration-dependent manner. CBZ inhibited carbachol-evoked Ca-45(2+) influx and catecholamine secretion at concentrations similar to those which suppressed Na-22(+) influx. 2) CBZ (4-120 mu mol/l) inhibited veratridine-induced Na-22(+) influx, Ca-45(2+) influx and catecholamine secretion. 3) CBZ (12 or 40-120 mu mol/l) suppressed 56 mmol/l K+-evoked Ca-45(2+) influxand catecholamine secretion, respectively. 4) Combination of CBZ withnitrendipine or omega-agatoxin-IVA produced further inhibition of 56 mmol/l K+- evoked Ca-45(2+) influx and catecholamine secretion, compared to the effect of CBZ alone, whereas CBZ-plus omega-conotoxin-GVIA did not produce any further inhibition. 5) CBZ (40 mu mol/l) attenuatedthe production of cyclic CMP caused by muscarine. These results suggest that CBZ at therapeutic concentrations (16-48 mu mol/l: 4-12 mu g/ml) inhibits catecholamine secretion by interfering with nicotinic acetylcholine receptor-associated ion channels, voltage-dependent Na+ channels and N-type voltage-dependent Ca2+ channels, and may have an antimuscarinic effect in adrenal medullary cells.

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Documento generato il 01/10/20 alle ore 03:19:09