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Titolo:
DIETHYLDITHIOCARBAMATE PROTECTION AGAINST CISPLATIN NEPHROTOXICITY - ANTIOXIDANT SYSTEM
Autore:
SOMANI SM; RAVI R; RYBAK LP;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT SURG SPRINGFIELD IL 62794
Titolo Testata:
Drug and chemical toxicology
fascicolo: 2-3, volume: 18, anno: 1995,
pagine: 151 - 170
SICI:
0148-0545(1995)18:2-3<151:DPACN->2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CISPLATIN; RAT-KIDNEY CORTEX; INDUCED LIPID-PEROXIDATION; RENAL CORTICAL SLICES; GLUTATHIONE PROTECTION; CIS-PLATINUM; SODIUM THIOSULFATE; TOXICITY; INVITRO; MITOCHONDRIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Somani et al., "DIETHYLDITHIOCARBAMATE PROTECTION AGAINST CISPLATIN NEPHROTOXICITY - ANTIOXIDANT SYSTEM", Drug and chemical toxicology, 18(2-3), 1995, pp. 151-170

Abstract

This investigation elucidates the role of antioxidant system in cisplatin induced nephrotoxicity and the nephroprotection with diethyldithiocarbamate (DDTC). Male Wistar rats were injected with 1) cisplatin; 2) cisplatin + DDTC and 3) vehicle control. Rats were sacrificed three days post-treatment and the corticomedullary junction of the kidney was isolated and were analyzed for GSH, GSSG, SOD, CAT, and GSH.Px. Serum creatinine increased (500% of control) following cisplatin administration which decreased to 200% of control with DDTC. Cisplatin treated rats showed depletion of GSH levels, while cisplatin + DDTC injected rats had GSH values similar to controls. SOD and GSH.Px activities werefound to be 63 and 40% of control following cisplatin administration which increased to 109 and 75% of control with DDTC respectively. Our findings suggest that cisplatin nephrotoxicity is mediated by impairedactivities of SOD and GSH-Px enzymes and by GSH depletion. The protective mechanism of DDTC against cisplatin nephrotoxicity is related to the prevention of GSH depletion and restoring SOD and GSH-Px activities in the kidney of rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:12:34