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Titolo:
CARDIOVASCULAR, HORMONAL, AND METABOLIC RESPONSES TO SEVERE PROLONGEDHEMORRHAGE IN ADULT SHEEP
Autore:
WINTOUR EM; MORITZ KM; POTOCNIK SJ;
Indirizzi:
UNIV MELBOURNE,HOWARD FLOREY INST EXPTL PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
American journal of veterinary research
fascicolo: 9, volume: 56, anno: 1995,
pagine: 1232 - 1240
SICI:
0002-9645(1995)56:9<1232:CHAMRT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE VASOPRESSIN; PREGNANT SHEEP; BLOOD-VOLUME; ACTH; CORTICOSTEROIDS; ERYTHROPOIETIN; STIMULATION; GLUTAMINE; CORTISOL; NEWBORN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Wintour et al., "CARDIOVASCULAR, HORMONAL, AND METABOLIC RESPONSES TO SEVERE PROLONGEDHEMORRHAGE IN ADULT SHEEP", American journal of veterinary research, 56(9), 1995, pp. 1232-1240

Abstract

Over a 54-hour period, blood was removed from 8 adult sheep (body weight, 38.1 +/- 0.5 kg, mean +/- SEM) in 9 episodes, 5 on day 1, 3 on day 2, and 1 on day 3. Cumulative blood loss was 1,630 +/- 63, 2,380 +/-71, and 2,693 +/- 69 ml on days 1, 2, and 3, respectively. Blood samples (20 ml) were collected from 5 control ewes (33.8 +/- 2.8 kg) at equivalent times. Over the first day, mean arterial blood pressure decreased in the hemorrhaged sheep from 101 +/- 2 mm of Hg to 76 +/- 5 mm of Hg; but returned to control values by the beginning of the second day and, thereafter, was not different from control values. Heart rate was increased after the first hemorrhage episode and remained high throughout the entire protocol. Over the entire period, there were statistically significant decreases in hematocrit, plasma osmolality, sodium,total calcium (P < 0.001), potassium, and chloride values (P < 0.05). There was no change in plasma phosphate, bicarbonate, creatinine, or magnesium concentrations and an increase in plasma urea nitrogen (P < 0.001) concentrations. Plasma arginine vasopressin concentration was increased significantly (P < 0.001) over the entire period. Plasma ACTHconcentration was significantly (P < 0.05) increased over time, but only some values on day 1 were significantly outside the normal range of the control group data. Because of wide variation between sheep, thegroup data for aldosterone were not significantly different from control values. Blood volume was restored on day 1 with fluid of osmolality, Na, and Cl composition equivalent to that of plasma. The effects ofarginine vasopressin were apparent by day 2, when the major decrease in osmolality and Na and Cl concentrations were observed. The sheep has good capacity to withstand severe, prolonged hemorrhage, most likelybecause of a large reserve of RBC in the spleen; hematocrit remained at 31% of control values when an estimated 100% of initial circulatingblood volume had been removed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 21:00:42