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Titolo:
ASSESSMENT OF SYSTOLIC WALL THICKENING USING TC-99M METHOXYISOBUTYLISONITRILE IN PATIENTS WITH CORONARY-ARTERY DISEASE - RELATION TO TL-201SCINTIGRAPHY WITH REINJECTION
Autore:
NICOLAI E; CUOCOLO A; PACE L; MAUREA S; NAPPI A; IMBRIACO M; MORISCO C; ARGENZIANO L; SALVATORE M;
Indirizzi:
UNIV NAPLES FEDERICO II,CNR,CTR MED NUCL,CATTEDRA MED NUCL,VIA POSILLIPO 66 I-80123 NAPLES ITALY UNIV NAPLES FEDERICO II,CNR,CTR MED NUCL,CATTEDRA MED NUCL I-80123 NAPLES ITALY UNIV NAPLES FEDERICO II,MED CLIN 1 NAPLES ITALY IST NAZL TUMORI NAPLES ITALY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 9, volume: 22, anno: 1995,
pagine: 1017 - 1022
SICI:
0340-6997(1995)22:9<1017:AOSWTU>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; METHOXY ISOBUTYL ISONITRILE; VENTRICULAR-FUNCTION; VIABLE MYOCARDIUM; TC-99M 2-METHOXY-ISOBUTYL-ISONITRILE; TL-201; REINJECTION; REDISTRIBUTION; PERFUSION; EXERCISE;
Keywords:
SYSTOLIC WALL THICKENING; TC-99M METHOXYISOBUTYLISONITRILE; TL-201 REINJECTION; CORONARY ARTERY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Nicolai et al., "ASSESSMENT OF SYSTOLIC WALL THICKENING USING TC-99M METHOXYISOBUTYLISONITRILE IN PATIENTS WITH CORONARY-ARTERY DISEASE - RELATION TO TL-201SCINTIGRAPHY WITH REINJECTION", European journal of nuclear medicine, 22(9), 1995, pp. 1017-1022

Abstract

The results of resting planar EGG-gated technetium-99m methoxyisobutylisonitrile (Tc-99m-MIBI) imaging were compared with those of thallium-201 (T1) re-injection after exercise-redistribution scintigraphy in 20 patients (19 men, 1 woman, mean age 53 +/- 10 years) with angiographically proven coronary artery disease. Eight normal subjects (seven men, one woman, mean age 50 +/- 8 years) constituted the control group. In these subjects, only resting Tc-99m-MIBI imaging was performed. Thestandardized percent count increase from end-diastole to end-systole was calculated as an index of wall thickening in 13 segments for each study. Regional wall thickening index (WTI) and Tc-99m-MIBI uptake were significantly different (P < 0.05) among segments classified as normal, reversible defects, irreversible defects with increased tracer uptake after re-injection (Re+) or irreversible defects with unchanged tracer uptake after re-injection (Re-) on T1 imaging. Furthermore, WTI and Tc-99m-MIBI uptake were significantly higher (P < 0.05) in Re-segments with moderate reduction of T1 uptake (greater than or equal to 50%of peak activity) than in Re-segments with severe reduction of T1 uptake (< 50% of peak activity). A significant relationship between WTI and the results of T1 scintigraphy was observed (rho = 0.71, P < 0.0001), The percentage of Re- segments with severe reduction of WTI was significantly higher compared to Re+ segments (64% vs 3%, P < 0.01). Furthermore, compared with moderate Re- segments, a significantly higher percentage of severe Re- segments showed a severe reduction of WTI (86%vs 48%, P < 0.01). Our data document a close relationship between Tc-99m-MIBI regional wall thickening, myocardial perfusion and T1 uptake after reinjection. The results of this study suggest that regional WTIdecreased significantly as myocardial perfusion decreased. In addition, regional wall thickening was preserved in segments with exercise-induced ischaemia and enhanced T1 uptake after re-injection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:09:57