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Titolo:
SCHIZOSTATIN, A POTENT SQUALENE SYNTHASE INHIBITOR FROM SCHIZOPHYLLUM-COMMUNE - ISOLATION, STRUCTURE ELUCIDATION, AND TOTAL SYNTHESIS
Autore:
TANIMOTO T; TSUJITA Y; HAMANO K; HARUYAMA H; KINOSHITA T; HOSOYA T; KANEKO S; TAGO K; KOGEN H;
Indirizzi:
SANKYO CO LTD,EXPLORAT CHEM RES LABS,1-2-58 HIROMACHI TOKYO 140 JAPAN SANKYO CO LTD,EXPLORAT CHEM RES LABS TOKYO 140 JAPAN SANKYO CO LTD,PHARMACOL & MOLEC BIOL RES LABS TOKYO 140 JAPAN SANKYO CO LTD,BIOMED RES LABS TOKYO 140 JAPAN SANKYO CO LTD,ANALYT & METAB RES LABS TOKYO 140 JAPAN SANKYO CO LTD,TSUKUBA RES LABS TOKYO 140 JAPAN
Titolo Testata:
Tetrahedron letters
fascicolo: 35, volume: 36, anno: 1995,
pagine: 6301 - 6304
SICI:
0040-4039(1995)36:35<6301:SAPSSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANDEM MASS-SPECTROMETRY; FATTY-ACIDS; LOCATION; METAL; BONDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Tanimoto et al., "SCHIZOSTATIN, A POTENT SQUALENE SYNTHASE INHIBITOR FROM SCHIZOPHYLLUM-COMMUNE - ISOLATION, STRUCTURE ELUCIDATION, AND TOTAL SYNTHESIS", Tetrahedron letters, 36(35), 1995, pp. 6301-6304

Abstract

The novel schizostatin (1) has been isolated as a potent inhibitor ofsqualene synthase. Its structure elucidation and total synthesis are described. Synthesis of the Z-isomer 12 and its biological activity are also reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:00:51