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Titolo:
DIVERGENCE OF INSULIN-LIKE-GROWTH-FACTORS-I AND INSULIN-LIKE-GROWTH-FACTORS-II IN THE ELASMOBRANCH, SQUALUS-ACANTHIAS
Autore:
DUGUAY SJ; CHAN SJ; MOMMSEN TP; STEINER DF;
Indirizzi:
UNIV CHICAGO,HOWARD HUGHES MED INST,5841 S MARYLAND AVE CHICAGO IL 60637 UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL CHICAGO IL 60637 UNIV VICTORIA,DEPT BIOCHEM & MICROBIOL VICTORIA BC V8W 3P6 CANADA
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 371, anno: 1995,
pagine: 69 - 72
SICI:
0014-5793(1995)371:1<69:DOIAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIBONUCLEIC-ACID; ATLANTIC HAGFISH; FACTOR CDNA; SEQUENCE; PREPROINSULIN; EVOLUTION; PRECURSOR; SUPERFAMILY; EXPRESSION;
Keywords:
INSULIN-LIKE GROWTH FACTOR; SQUALUS ACANTHIAS (SPINY DOGFISH SHARK);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Duguay et al., "DIVERGENCE OF INSULIN-LIKE-GROWTH-FACTORS-I AND INSULIN-LIKE-GROWTH-FACTORS-II IN THE ELASMOBRANCH, SQUALUS-ACANTHIAS", FEBS letters, 371(1), 1995, pp. 69-72

Abstract

Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes, In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II. Between these groups the elasmobranchs occupy a critical position in terms of the phylogeny of IGFs. We sought to determine if gene duplication and divergence of IGF-I and IGF-II occurred before or after divergence of elasmobranchs from other vertebrates by cloning IGF-like molecules from Squalus acanthias. Our analysis shows that Squalus liver produces two distinct IGF-like molecules, One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and divergedin an ancestor of the extant gnathostomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:51:22