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Titolo:
IMMUNE-RESPONSE TO HEPATITIS-C VIRUS CORE PROTEIN IN MICE
Autore:
HARASE I; MORIYAMA T; KANEKO T; KITA H; NOMURA M; SUZUKI G; OHNISHI H; MUTO Y; IMAWARI M;
Indirizzi:
JICHI MED SCH,LIVER STUDY LAB,3311-1 YAKUSHIJI MINAMI KAWACHI TOCHIGI32904 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3 TOKYO 113 JAPAN ASAHI CHEM IND CO LTD,LIFE SCI RES INST SHIZUOKA JAPAN NATL INST RADIOL SCI,DIV RADIAT HLTH CHIBA JAPAN GIFU UNIV,SCH MED,DEPT INTERNAL MED 1 GIFU 500 JAPAN
Titolo Testata:
Immunology and cell biology
fascicolo: 4, volume: 73, anno: 1995,
pagine: 346 - 352
SICI:
0818-9641(1995)73:4<346:ITHVCP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; NON-A; ANTIGENS; PEPTIDES; EPITOPE; BINDING; LINES;
Keywords:
B CELL EPITOPE; HCV CORE PROTEIN; MICE; TH CELL EPITOPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
I. Harase et al., "IMMUNE-RESPONSE TO HEPATITIS-C VIRUS CORE PROTEIN IN MICE", Immunology and cell biology, 73(4), 1995, pp. 346-352

Abstract

To analyse the immune response to the hepatitis C virus (HCV) core protein, we immunized mice with the protein, BALB/c (H-2(d)) and C3H/He (H-2(k)) mice were high responders, while C57BL/6 (H-2(b)) mice were low responders in terms of Th cell proliferative responses. All the strains showed comparable levels of antibody responses to the HCV core protein. The Th cell lines recognized residues 61-90 of the HCV core protein in the context of I-A(d) (BALB/c) and residues 11-30 in the context of I-E(k) (C3H/He), respectively. The Th cell lines were restrictedby I-A(b) in C57BL/6 mice but recognized no synthetic peptide that spanned the region, although derivative clones from the line recognized residues 1-20 and 91-110 of the HCV core protein, respectively. The Thcell lines were Th1 subset in all three strains based on the profile of lymphokine secretion, The major B cell epitope of the protein was found to be within residues 21-40 of the HCV core protein in all three strains. These observations should be useful for better understanding of the immune response to the HCV core protein in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 06:52:21