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Titolo:
21-HYDROXYLASE AUTOANTIBODIES IN ADULT PATIENTS WITH ENDOCRINE AUTOIMMUNE-DISEASES ARE HIGHLY SPECIFIC FOR ADDISONS-DISEASE
Autore:
FALORNI A; LAURET S; NIKOSHKOV A; PICCHIO ML; HALLENGREN B; VANDEWALLE CL; GORUS FK; TORTOIOLI C; LUTHMAN H; BRUNETTI P; SANTEUSANIO F;
Indirizzi:
UNIV PERUGIA,DEPT INTERNAL MED & ENDOCRINE METAB SCI,VIA E DAL POZZO I-06126 PERUGIA ITALY LUND UNIV,DEPT ENDOCRINOL MALMO SWEDEN KAROLINSKA INST,DEPT MOL MED STOCKHOLM SWEDEN FREE UNIV BRUSSELS,DEPT ENDOCRINOL & METAB,DIABET RES CTR BRUSSELS BELGIUM BDR BRUSSELS BELGIUM
Titolo Testata:
Clinical and experimental immunology
fascicolo: 2, volume: 107, anno: 1997,
pagine: 341 - 346
SICI:
0009-9104(1997)107:2<341:2AIAPW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; GLUTAMIC-ACID DECARBOXYLASE; ISLET-CELL-ANTIBODIES; STEROID 21-HYDROXYLASE; CYTOCHROME-P450 ENZYMES; ADRENAL INSUFFICIENCY; MAJOR AUTOANTIGEN; CLINICAL ONSET; ASSAY;
Keywords:
ADRENAL AUTOANTIBODIES; ADDISONS DISEASE; POLYENDOCRINOPATHY; RADIOIMMUNOASSAY; RECOMBINANT AUTOANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Falorni et al., "21-HYDROXYLASE AUTOANTIBODIES IN ADULT PATIENTS WITH ENDOCRINE AUTOIMMUNE-DISEASES ARE HIGHLY SPECIFIC FOR ADDISONS-DISEASE", Clinical and experimental immunology, 107(2), 1997, pp. 341-346

Abstract

The diagnostic specificity of recombinant 21-hydroxylase autoantibodies (21OH-Ab) for Addison's disease was tested in adult patients with either Graves' disease (GD), insulin-dependent diabetes mellitus (IDDM), or polyendocrinopathy, as well as in healthy controls. Using a radiobinding assay with in vitro translated recombinant human 21-hydroxylase, we found 21OH-Ab in 24/28 (86%) idiopathic Addison patients, and using an immunofluorescence assay we found adrenal cortex autoantibodies(ACA) in 12/28 (43%) patients (P = 0.002). All tie 12 ACA-positive sera were also positive for 21OH-Ab and ACA were found in 11/15 (73%) patients with less than 15 years and in 1/13 (8%) patients with 15-38 years of disease duration (P = 0.002). 21OH-Ab were present in 3/92 (3%)patients with GD, in 1/180 (0.6%) with IDDM and in 0/106 healthy subjects. The 21OH-Ab-positive GD and IDDM patients were also positive forACA. None of 17 patients with polyendocrinopathy, but without Addison's disease, had 21OH-Ab. None of the 180 Belgian IDDM patients had Addison's disease or developed an adrenal insufficiency at follow up. In two out of three Graves patients, the presence of 21OH-Ab was associated with clinical and biochemical signs of adrenal insufficiency. Of the 89 21OH-Ab-negative patients with GD none had Addison's disease at the time of blood sampling, and 79 were followed up for 5.6-7.5 years and none developed clinical signs of adrenal insufficiency. We concludethat the presence of 21OH-Ab in patients with endocrine autoimmune diseases is highly specific for Addison's disease.

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Documento generato il 05/12/20 alle ore 04:23:51