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Titolo:
THE EFFECTS OF A SELECTIVE CAMP-PHOSPHODIESTERASE INHIBITOR, ROLIPRAM, ON METHAMPHETAMINE-INDUCED BEHAVIOR
Autore:
IYO M; MAEDA Y; INADA T; KITAO Y; SASAKI H; FUKUI S;
Indirizzi:
NATL KOHNODAI HOSP,NATL CTR NEUROL & PSYCHIAT,NATL INST MENTAL HLTH,DEPT PSYCHIAT,1-7-3 KOHNODAI ICHIKAWA CHIBA 272 JAPAN NATL KOHNODAI HOSP,NATL CTR NEUROL & PSYCHIAT,NATL INST MENTAL HLTH,DEPT PSYCHIAT ICHIKAWA CHIBA 272 JAPAN NATL KOHNODAI HOSP,NATL CTR NEUROL & PSYCHIAT,NATL INST MENTAL HLTH ICHIKAWA CHIBA 272 JAPAN
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 13, anno: 1995,
pagine: 33 - 39
SICI:
0893-133X(1995)13:1<33:TEOASC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN DOPAMINE-RECEPTORS; LOCOMOTOR-ACTIVITY; D-1 ANTAGONIST; C-FOS; STEREOTYPED BEHAVIOR; NUCLEUS-ACCUMBENS; D-AMPHETAMINE; RAT STRIATUM; SCH-23390; COCAINE;
Keywords:
METHAMPHETAMINE; DOPAMINE; CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE (CAMP); ROLIPRAM; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Iyo et al., "THE EFFECTS OF A SELECTIVE CAMP-PHOSPHODIESTERASE INHIBITOR, ROLIPRAM, ON METHAMPHETAMINE-INDUCED BEHAVIOR", Neuropsychopharmacology, 13(1), 1995, pp. 33-39

Abstract

The effects of rolipram, a selective cAMP phosphodiesterase inhibitor, on locomotor activity, rearing, and stereotyped behavior (sniffing, repetitive head movements) induced by methamphetamine (MAP) over 1 hour were investigated in rats. Coadministration of rolipram (4 mg/kg IP)significantly attenuated the responses of locomotor activity, rearingand repetitive head movements to MAP (2,4 or 8 mg/kg IP). Rolipram (0.5, 1, 2, or 4 mg/kg IF) dose-dependently inhibited locomotor hyperactivity and rearing induced by 4 mg/kg of MAP. The rearing was completely inhibited by 4 mg/kg of rolipram, whereas the maximal inhibition of the locomotor hyperactivity was about 50%. However, rolipram did not alter MAP-induced sniffing and repetitive head movements. These resultsindicate that there is heterogeneity in the response of MAP-induced behavior to rolipram, suggesting that MAP-induced behavioral alterationmay be partly regulated by cAMP levels in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:11:37