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Titolo:
STABILITY AND ACTIVITY OF ALTEPLASE WITH INJECTABLE DRUGS COMMONLY USED IN CARDIAC THERAPY
Autore:
LAM XM; WARD CA; DUMEE CPRD;
Indirizzi:
GENENTECH INC,DEPT PHARMACEUT RES & DEV,460 PT SAN BRUNO BLVD S SAN FRANCISCO CA 94080 GENENTECH INC,DEPT PROD DEV S SAN FRANCISCO CA 94080 COR THERAPEUT INC,DEPT PHARMACEUT SCI S SAN FRANCISCO CA 00000
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 17, volume: 52, anno: 1995,
pagine: 1904 - 1909
SICI:
1079-2082(1995)52:17<1904:SAAOAW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR;
Keywords:
ALTEPLASE; ANALGESICS AND ANTIPYRETICS; ANTICOAGULANTS; CARDIAC DRUGS; DEXTROSE; DILUENTS; DOBUTAMINE HYDROCHLORIDE; DOPAMINE HYDROCHLORIDE; HEPARIN SODIUM; INCOMPATIBILITIES; INJECTIONS; MORPHINE SULFATE; SODIUM CHLORIDE; STABILITY; STORAGE; THROMBOLYTIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
X.M. Lam et al., "STABILITY AND ACTIVITY OF ALTEPLASE WITH INJECTABLE DRUGS COMMONLY USED IN CARDIAC THERAPY", American journal of health-system pharmacy, 52(17), 1995, pp. 1904-1909

Abstract

The stability, activity, and compatibility of alteplase with eight drugs frequently used in cardiovascular disease were studied. Alteplase 1 mg/mL was mixed with each of the following: heparin sodium 80 units/mL in 0.9% sodium chloride injection, dobutamine 10 mg/mL (as the hydrochloride salt) in 0.9% sodium chloride injection or 5% dextrose injection, dopamine hydrochloride 1.6 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection, morphine sulfate 2 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection, lidocaine hydrochloride 8 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection, propranolol hydrochloride 1 mg/mL, metoprolol tartrate 1 mg/mL, or nitroglycerin 0.8 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection. Each mixture was assayed immediately and after storage for 24 hours at 25 degrees C; mixtures containing heparin were also assayed at4 hours. The alteplase concentration and percentage of the single-chain molecule in each mixture were analyzed by using size-exclusion high-performance liquid chromatography (HPLC). Alteplase bioactivity was determined by a clot-lysis assay. Drug concentrations were assayed by HPLC, pH values of the mixtures were determined, and the mixtures were visually inspected. Instability was defined as a >10% decrease in concentration; inactivity was defined as a >10% decrease in activity; incompatibility was defined as detection of a precipitate, opalescence, orcolor change. Alteplase was not stable in the presence of heparin sodium, morphine sulfate, or dobutamine and was not active in the presence of dopamine hydrochloride. Alteplase was compatible with and stable and active (in vitro) in the presence of Lidocaine hydrochloride, propranolol hydrochloride, metoprolol tartrate, or nitroglycerin. Alteplase was compatible with and stable and active in the presence of four ofthe eight drugs tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:28:13