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Titolo:
ALTERATION OF BLOOD-BRAIN-BARRIER IN HUMAN BRAIN-TUMORS - COMPARISON OF[F-18]FLUORODEOXYGLUCOSE, [C-11] METHIONINE AND RB-82 USING PET
Autore:
ROELCKE U; RADU EW; VONAMMON K; HAUSMANN O; MAGUIRE RP; LEENDERS KL;
Indirizzi:
PAUL SCHERRER INST,PET PROGRAM CH-5232 VILLIGEN SWITZERLAND PAUL SCHERRER INST,PET PROGRAM CH-5232 VILLIGEN SWITZERLAND UNIV BASEL HOSP,DEPT NEURORADIOL CH-4031 BASEL SWITZERLAND UNIV ZURICH HOSP,DEPT NEUROSURG CH-8091 ZURICH SWITZERLAND UNIV BASEL HOSP,DEPT NEUROSURG CH-4031 BASEL SWITZERLAND
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 132, anno: 1995,
pagine: 20 - 27
SICI:
0022-510X(1995)132:1<20:AOBIHB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; METHIONINE ACCUMULATION; DEXAMETHASONE TREATMENT; GLUCOSE TRANSPORTER; TO-BRAIN; FLOW; ASTROCYTOMAS; METABOLISM; GLIOMAS; EDEMA;
Keywords:
BLOOD-BRAIN BARRIER; BRAIN TUMORS; PET; [F-18] FLUORODEOXYGLUCOSE; [C-11] METHIONINE; RUBIDINM-82;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
U. Roelcke et al., "ALTERATION OF BLOOD-BRAIN-BARRIER IN HUMAN BRAIN-TUMORS - COMPARISON OF[F-18]FLUORODEOXYGLUCOSE, [C-11] METHIONINE AND RB-82 USING PET", Journal of the neurological sciences, 132(1), 1995, pp. 20-27

Abstract

The influence of the blood-brain barrier (BBB) on tracer uptake was investigated in 21 patients with gliomas and meningiomas using PET, [F-18]fluorodeoxyglucose (FDG), [C-18]methionine (MET) and the K+ analog rubidium-82(RUB) whose uptake into brain is largely prevented if the BBB is intact. Tracer uptake was quantitated by (1) multiple time graphical plotting providing tracer distribution volume (V-D), unidirectional tracer uptake (K-i) and (2) normalized uptake (NU) which is a measure of net tissue radioactivity related to administered activity and body weight. V-D, K-i and NU of MET were higher in meningiomas compared to gliomas and were significantly correlated with NU RUB (Spearman rank: p < 0.005 (V-D), p < 0.05 (K-i), p < 0.001 (NU)). NU MET correlatedwith V-D (p < 0.001) and K-i (p < 0.005) of MET. For FDG, tumor V-D was in the range of contralateral cortex K-i and NU values of FDG were highest in glioblastomas. NU of FDG correlated significantly with K-i of FDG (p < 0.005) but not with V-D. The results suggest, that alteration of MET uptake in tumors is governed by changes of tracer influx across the BBB, whereas FDG uptake is related to tracer metabolism. Thismakes FDG the appropriate tracer particularly for the differential diagnosis of contrast enhancing lesions in operated and irradiated patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:03:56