Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF LOVASTATIN ON THE DEVELOPMENT OF POLYCYSTIC KIDNEY-DISEASE IN THE HAN-SPRD RAT
Autore:
GILE RD; COWLEY BD; GATTONE VH; ODONNELL MP; SWAN SK; GRANTHAM JJ;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT MED,DIV NEPHROL & HYPERTENS KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT MED,DIV NEPHROL & HYPERTENS KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 66160 HENNEPIN CTY MED CTR,DEPT MED MINNEAPOLIS MN 00000
Titolo Testata:
American journal of kidney diseases
fascicolo: 3, volume: 26, anno: 1995,
pagine: 501 - 507
SICI:
0272-6386(1995)26:3<501:EOLOTD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATION; SECRETION; CELLS;
Keywords:
CYST; AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE; PROGRESSIVE RENAL DISEASE; RENAL INSUFFICIENCY; CELL PROLIFERATION; INTERSTITIAL FIBROSIS; INTERSTITIAL INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Gile et al., "EFFECT OF LOVASTATIN ON THE DEVELOPMENT OF POLYCYSTIC KIDNEY-DISEASE IN THE HAN-SPRD RAT", American journal of kidney diseases, 26(3), 1995, pp. 501-507

Abstract

Proliferation of tubular epithelial cells is a major element leading to cyst formation in Han:SPRD rats with autosomal dominant polycystic kidney disease (PKD), ras proteins are important in the control of renal cell proliferation, and res gene expression is increased in PKD, Farnesyl pyrophosphate, an intermediate in the conversion of acetyl-CoA to cholesterol, is required for the activation of ras guanosine triphosphate (GTP)-binding proteins that are important in the execution of several cellular functions, including cell proliferation, 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, such as lovastatin, reduce farnesyl production in responsive cells and thereby have potentialfar ameliorating the accelerated epithelial cell proliferation of PKD. We administered lovastatin to heterozygous (Cy/+) Han:SPRD rats (4 mg/kg/d subcutaneously) from age 4 to 10 weeks, a period of rapid cystic disease progression in these animals, Untreated male Cy/+ rats developed larger cystic kidneys and had more severe renal functional impairment than females, as reported previously, In males, lovastatin significantly decreased cystic kidney size (referenced to body weight), the volume density of cysts, and the serum urea nitrogen level 14.5%, 24.4%, and 25.6/%, respectively, The corresponding changes in females wereinsignificant, and lovastatin had no effect on kidney weight or serumurea nitrogen in homozygous (+/+) normal male animals. On the basis of these results we conclude that lovastatin diminishes the severity ofPKD in heterozygous male Han:SPRD rats. (C) 1995 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:26:35