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Titolo:
DISTRIBUTION OF TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS IN THE MAMMALIAN RETINA
Autore:
ANDERSON DH; GUERIN CJ; HAGEMAN GS; PFEFFER BA; FLANDERS KC;
Indirizzi:
UNIV CALIF SANTA BARBARA,NEUROSCI RES INST SANTA BARBARA CA 93106 HENRY FORD HOSP,EYE CARE SERV DETROIT MI 48202 ST LOUIS UNIV,SCH MED,ANHEUSER BUSCH EYE INST ST LOUIS MO 00000 AMER CYANAMID CO,STORZ OPHTHALM DIV PEARL RIVER NY 10965 NCI,CHEMOPREVENT LAB BETHESDA MD 20892
Titolo Testata:
Journal of neuroscience research
fascicolo: 1, volume: 42, anno: 1995,
pagine: 63 - 79
SICI:
0360-4012(1995)42:1<63:DOTGII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; EPITHELIAL-CELLS; NERVOUS-SYSTEM; MESSENGER-RNA; TGF-BETA; LOCALIZATION; FACTOR-BETA-1; ANTIBODIES; HYPOXIA; GROWTH-FACTOR-BETA-1;
Keywords:
GROWTH FACTORS; RETINAL PIGMENTED EPITHELIUM; PHOTORECEPTORS; MUELLER CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Anderson et al., "DISTRIBUTION OF TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS IN THE MAMMALIAN RETINA", Journal of neuroscience research, 42(1), 1995, pp. 63-79

Abstract

The distribution of transforming growth factor-beta (TGF-beta) was examined in the posterior segment of the monkey, human, and feline eye using antisera to TGF-beta 1, TGF-beta 2, or TGF-beta 3. A number of different antibodies, tissue processing methods, immunolocalization techniques, and microscopic imaging systems were used in an attempt to gain a more comprehensive picture of TGF-beta isoform distribution in theretina and retinal pigmented epithelium (RPE), The results are generally consistent in identifying one or more of the three TGF-beta isoforms in the cytoplasm of a small, overlapping subset of cells, RPE cells, photoreceptors, Mueller cells, ganglion cells, hyalocytes, and cellsassociated with choroidal and retinal vessels are all represented in this immunoreactive population, No evidence of extracellular labeling was noted, The intracellular distribution of the three isoforms is distinctly different in photoreceptors. Anti-TGF-beta 1 precursor and anti-TGF-beta 2 immunoreactivity is confined primarily to rod outer segments, whereas anti-TGF-beta 3 immunoreactivities are restricted to mitochondria within inner segments, In the RPE, dusters of anti-TGF-beta 2positive cytoplasmic granules are located near the cells' lateral borders, whereas anti-TGF-beta 3 labeling is concentrated apically. Theseresults provide baseline information from which new hypotheses regarding the function(s) of TGF-beta isoforms in the retina can be formulated. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:59:22