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Titolo:
INFLUENCE OF COMBINED TREATMENT WITH NMDA AND NON-NMDA RECEPTOR ANTAGONISTS ON ELECTROCONVULSIONS IN MICE
Autore:
CZUCZWAR SJ; BOROWICZ KK; KLEINROK Z; TUTKA P; ZARNOWSKI T; TURSKI WA;
Indirizzi:
UNIV LUBECK,SCH MED,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 281, anno: 1995,
pagine: 327 - 333
SICI:
0014-2999(1995)281:3<327:IOCTWN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT ANXIOLYTIC PROPERTIES; AMINO-ACID ANTAGONISTS; INDUCED SEIZURES; ANTIEPILEPTIC DRUGS; COMPETITIVE ANTAGONISTS; ANTICONVULSANT ACTIVITY; POTENT ANTICONVULSANT; MAXIMAL ELECTROSHOCK; 10-IMINE MK-801; KINDLING MODEL;
Keywords:
AMPA RECEPTOR ANTAGONIST; NMDA RECEPTOR ANTAGONIST; SEIZURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Czuczwar et al., "INFLUENCE OF COMBINED TREATMENT WITH NMDA AND NON-NMDA RECEPTOR ANTAGONISTS ON ELECTROCONVULSIONS IN MICE", European journal of pharmacology, 281(3), 1995, pp. 327-333

Abstract

-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate (AMPA/kainate) receptor antagonists (at subthreshold doses against electroconvulsions), -4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466 at maximally 5 mg/kg) and 3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX at maximally 20 mg/kg) enhanced the protective effects of NMDA receptor antagonists, MK-801 (dizocilpine) or (2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid (D-CPP-ene), against electroconvulsions. Similarly, MK-801 or D-CPP-ene reduced the ED,, values of both NBQX and GYKI 52466 against maximal electroshock. The adverse effects of D-CPP-ene, evaluated in the chimney and rotorod tests, were potentiated by both GYKI 52466 (2.5 mg/kg) and NBQX (10 mg/kg). Also, D-CPP-ene (0.1 mg/kg) worsened the motor performance of mice pretreated with GYKI 52466 in the rotorod test. Neither MK-801 (0.025 mg/kg) nor D-CPP-ene (0.1 mg/kg) affected the NBQX-induced impairment of motor coordination. Similarly, GYKI 52466 (2.5 mg/kg) or NBQX (10 mg/kg) did not influence the performance of mice treated with MK-801 (0.2 mg/kg). It may be concluded that the blockade of more than one subtype of glutamate receptors leads to a more pronounced anticonvulsive effect when compared with the effect of blockade of an individual receptor subtype. In some cases more efficient seizure protection was not associated with increased adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:35:11